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http://hdl.handle.net/2445/124283
Title: | Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization |
Author: | Villacampa, Pilar Menger, Katja E Abelleira, Laura Ribeiro, Joana Duran, Yanai Smith, Alexander J. Ali, Robin R. Luhmann, Ulrich F. Bainbridge, James W. B. |
Keywords: | Malalties de la retina Isquèmia Ischemia Retinal diseases |
Issue Date: | 26-Jun-2017 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Retinal ischemia and pathological angiogenesis cause severe impairment of sight. Oxygen-induced retinopathy (OIR) in young mice is widely used as a model to investigate the underlying pathological mechanisms and develop therapeutic interventions. We compared directly the conventional OIR model (exposure to 75% O-2 from postnatal day (P) 7 to P12) with an alternative, accelerated version (85% O-2 from P8 to P11). We found that accelerated OIR induces similar pre-retinal neovascularization but greater retinal vascular regression that recovers more rapidly. The extent of retinal gliosis is similar but neuroretinal function, as measured by electroretinography, is better maintained in the accelerated model. We found no systemic or maternal morbidity in either model. Accelerated OIR offers a safe, reliable and more rapid alternative model in which pre-retinal neovascularization is similar but retinal vascular regression is greater. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0179759 |
It is part of: | PLoS One, 2017, vol. 12, num. 6 |
URI: | http://hdl.handle.net/2445/124283 |
Related resource: | https://doi.org/10.1371/journal.pone.0179759 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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journal.pone.0179759.pdf | 9.58 MB | Adobe PDF | View/Open |
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