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http://hdl.handle.net/2445/124289
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DC Field | Value | Language |
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dc.contributor.author | Fernández Mateos, Javier | - |
dc.contributor.author | Seijas-Tamayo, Raquel | - |
dc.contributor.author | Adansa Klain, Juan Carlos | - |
dc.contributor.author | Pastor Borgoñón, Miguel | - |
dc.contributor.author | Pérez Ruiz, Elisabeth | - |
dc.contributor.author | Mesía Nin, Ricard | - |
dc.contributor.author | Barco, Elvira del | - |
dc.contributor.author | Salvador Coloma, Carmen | - |
dc.contributor.author | Rueda Dominguez, Antonio | - |
dc.contributor.author | Caballero Daroqui, Javier | - |
dc.contributor.author | Fernández Ruiz, Encarnación | - |
dc.contributor.author | Cruz Hernández, Juan Jesús | - |
dc.contributor.author | González Sarmiento, Rogelio | - |
dc.date.accessioned | 2018-09-05T08:21:24Z | - |
dc.date.available | 2018-09-05T08:21:24Z | - |
dc.date.issued | 2017-07-31 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124289 | - |
dc.description.abstract | Head and neck squamous cell carcinoma (HNSCC) is the sixth cancer on incidence worldwide. Tobacco and alcohol consumption are the most classical risk factors associated with its development. Autophagy process has a dual effect both in tumourigenesis and tumour suppressing activity. To investigate the importance of this pathway in HNSCC susceptibility, a risk factor matched case-control association study was performed with four candidate polymorphisms in autophagy genes (ATG2B, ATG5, ATG10, ATG16L1). We found an association between the variant in ATG10 rs1864183 and a higher susceptibility to develop laryngeal cancer, ATG2B rs3759601 and pharyngeal cancer and ATG16L1 rs2241880 and oral carcinoma. ATG5 rs2245214 SNP was not associated with any location. Overall, our results indicate the importance of the autophagy pathway in the susceptibility of head and neck squamous cell carcinoma and demonstrate the heterogeneity between its locations encompassed under a single terminology. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-07270-0 | - |
dc.relation.ispartof | Scientific Reports, 2017, vol. 7 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-017-07270-0 | - |
dc.rights | cc by (c) Fernández Mateos et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Autofàgia | - |
dc.subject.classification | Polimorfisme genètic | - |
dc.subject.classification | Tumors | - |
dc.subject.other | Autophagy | - |
dc.subject.other | Genetic polymorphisms | - |
dc.title | Analysis of autophagy gene polymorphisms in Spanish patients with head and neck squamous cell carcinoma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:03:09Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28761177 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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Fernandez-MateosJ.pdf | 1.05 MB | Adobe PDF | View/Open |
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