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http://hdl.handle.net/2445/124315
Title: | Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus |
Author: | Pinazo, Maria-Jesus Espinosa Garriga, Gerard Gállego Culleré, M. (Montserrat) López-Chejade, Paulo Luis Urbina, Julio A. Gascón i Brustenga, Joaquim |
Keywords: | Malaltia de Chagas Quimioteràpia Triazoles Chagas' disease Chemotherapy Triazoles |
Issue Date: | Apr-2010 |
Publisher: | American Society of Tropical Medicine and Hygiene |
Abstract: | American Trypanosomiasis or Chagas disease (CD) is a neglected disease that affects Latin American people worldwide. Two old antiparasitic drugs, benznidazole and nifurtimox, are currently used for specific CD treatment with limited efficacy in chronic infections and frequent side effects. New drugs are needed for patients with chronic CD as well as for immunosuppressed patients, for whom the risk of reactivation is life-threatening. We describe a case of chronic CD and systemic lupus erythematosus (SLE) that required immunosuppression to control the autoimmune process. It was found that benznidazole induced a reduction, but not an elimination, of circulating Trypanosoma cruzi levels, whereas subsequent treatment with posaconazole led to a successful resolution of the infection, despite the maintenance of immunosuppressive therapy. |
Note: | Reproducció del document publicat a: https://doi.org/10.4269/ajtmh.2010.09-0620 |
It is part of: | American Journal of Tropical Medicine and Hygiene, 2010, vol. 82, num. 4, p. 583-587 |
URI: | http://hdl.handle.net/2445/124315 |
Related resource: | https://doi.org/10.4269/ajtmh.2010.09-0620 |
ISSN: | 0002-9637 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) |
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