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http://hdl.handle.net/2445/124324
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DC Field | Value | Language |
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dc.contributor.author | Fortner, Renée T. | - |
dc.contributor.author | Sarink, Danja | - |
dc.contributor.author | Schock, Helena | - |
dc.contributor.author | Johnson, Theron | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Olsen, Anja | - |
dc.contributor.author | Overvad, Kim | - |
dc.contributor.author | Affret, Aurélie | - |
dc.contributor.author | His, Mathilde | - |
dc.contributor.author | Boutron-Ruault, Marie-Christine | - |
dc.contributor.author | Boeing, Heiner | - |
dc.contributor.author | Trichopoulou, Antonia | - |
dc.contributor.author | Naska, Androniki | - |
dc.contributor.author | Orfanos, Philippos | - |
dc.contributor.author | Palli, Domenico | - |
dc.contributor.author | Sieri, Sabina | - |
dc.contributor.author | Mattiello, Amalia | - |
dc.contributor.author | Tumino, Rosario | - |
dc.contributor.author | Ricceri, Fulvio | - |
dc.contributor.author | Bueno de Mesquita, H. Bas | - |
dc.contributor.author | Peeters, Petra H. M. | - |
dc.contributor.author | van Gils, Carla H. | - |
dc.contributor.author | Weiderpass, Elisabete | - |
dc.contributor.author | Lund, Eiliv | - |
dc.contributor.author | Quirós, J. Ramón | - |
dc.contributor.author | Agudo, Antonio | - |
dc.contributor.author | Sánchez, María José | - |
dc.contributor.author | Chirlaque, María Dolores | - |
dc.contributor.author | Ardanaz, Eva | - |
dc.contributor.author | Dorronsoro, Miren | - |
dc.contributor.author | Key, Timothy J. | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Rinaldi, Sabina | - |
dc.contributor.author | Dossus, Laure | - |
dc.contributor.author | Gunter, Marc J. | - |
dc.contributor.author | Merritt, Melissa A. | - |
dc.contributor.author | Riboli, Elio | - |
dc.contributor.author | Kaaks, Rudolf | - |
dc.date.accessioned | 2018-09-06T07:11:35Z | - |
dc.date.available | 2018-09-06T07:11:35Z | - |
dc.date.issued | 2017-02-08 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124324 | - |
dc.description.abstract | Background: Circulating osteoprotegerin (OPG), a member of the receptor activator of nuclear factor kappa-B (RANK) axis, may influence breast cancer risk via its role as the decoy receptor for both the RANK ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Circulating OPG and breast cancer risk has been examined in only one prior study. Methods: A case-control study was nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 2008 incident invasive breast cancer cases (estrogen receptor (ER)+, n = 1622; ER-, n = 386), matched 1: 1 to controls, were included in the analysis. Women were predominantly postmenopausal at blood collection (77%); postmenopausal women included users and non-users of postmenopausal hormone therapy (HT). Serum OPG was quantified with an electrochemiluminescence assay. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression. Results: The associations between OPG and ER+ and ER-breast cancer differed significantly. Higher concentrations of OPG were associated with increased risk of ER-breast cancer (top vs. bottom tertile RR = 1.93 [95% CI 1.24-3.02]; p(trend) = 0.03). We observed a suggestive inverse association for ER+ disease overall and among women premenopausal at blood collection. Results for ER-disease did not differ by menopausal status at blood collection (p(het) = 0.97), and we observed no heterogeneity by HT use at blood collection (p(het) >= 0.43) or age at breast cancer diagnosis (p(het) >= 0.30). Conclusions: This study provides the first prospective data on OPG and breast cancer risk by hormone receptor subtype. High circulating OPG may represent a novel risk factor for ER-breast cancer. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12916-017-0786-8 | - |
dc.relation.ispartof | BMC Medicine, 2017, vol. 15, num. 26 | - |
dc.relation.uri | https://doi.org/10.1186/s12916-017-0786-8 | - |
dc.rights | cc by (c) Fortner et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Necrosi | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Necrosis | - |
dc.title | Osteoprotegerin and breast cancer risk by hormone receptor subtype: a nested case-control study in the EPIC cohort | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:10:53Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/623984/EU//RANKL_OPG | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28173834 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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FortnerRT.pdf | 371.91 kB | Adobe PDF | View/Open |
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