Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/124348
Title: | Genetic Polymorphisms In Estrogen-related Genes And The Risk Of Breast Cancer Among Han Chinese Women |
Author: | Sun, Min-Ying Du, Hong-Yan Zhu, An-Na Liang, Hui-Ying Ruiz de Garibay, Gorka Li, Fen-Xia Li, Ming Yang, Xue-Xi |
Keywords: | Càncer de mama Estrògens Breast cancer Estrogen |
Issue Date: | 1-Feb-2015 |
Publisher: | MDPI |
Abstract: | Exposure to high levels of estrogen is considered an important risk factor for susceptibility to breast cancer. Common polymorphisms in genes that affect estrogen levels may be associated with breast cancer risk, but no comprehensive study has been performed among Han Chinese women. In the present study, 32 single-nucleotide polymorphisms (SNPs) in estrogen-related genes were genotyped using the MassARRAY IPLEX platform in 1076 Han Chinese women. Genotypic and allelic frequencies were compared between case and control groups. Unconditional logistic regression was used to assess the effects of SNPs on breast cancer risk. Associations were also evaluated for breast cancer subtypes stratified by estrogen receptor (ER) and progesterone receptor (PR) status. Case-control analysis showed a significant relation between heterozygous genotypes of rs700519 and rs2069522 and breast cancer risk (OR = 0.723, 95% CI = 0.541-0.965, p = 0.028 and OR = 1.500, 95% CI = 1.078-2.087, p = 0.016, respectively). Subgroup comparisons revealed that rs2446405 and rs17268974 were related to ER status, and rs130021 was associated with PR status. Our findings suggest that rs700519 and rs2069522 are associated with susceptibility to breast cancer among the Han Chinese population and have a cumulative effect with three other identified SNPs. Further genetic and functional studies are needed to identify additional SNPs, and to elucidate the underlying molecular mechanisms. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms16024121 |
It is part of: | International Journal of Molecular Sciences, 2015, vol. 16, num. 2, p. 4121-4135 |
URI: | http://hdl.handle.net/2445/124348 |
Related resource: | https://doi.org/10.3390/ijms16024121 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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