Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/124352
Title: Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Author: McKay, James D.
Hung, Rayjean J.
Han, Younghun
Zong, Xuchen
Carreras Torres, Robert
Christiani, David C.
Caporaso, Neil E.
Johansson, Mattias
Xiao, Xiangjun
Li, Yafang
Byun, Jinyoung
Jiang, Xia
Melander, Olle
Tyndale, Rachel F.
Diao, Nancy
Chenevix Trench, Georgia
Beesley, Jonathan
Bosse, Yohan
Aldrich, Melinda C.
Yuan, Jian-Min
Chanock, Stephen
Mellemgaard, Anders
Brennan, Paul
Landi, Maria Teresa
Amos, Christopher I.
Ji, Xuemei
Su, Li
Haugen, Aage
Liu, Geoffrey
Timofeeva, Maria N.
Bojesen, Stig E.
Wu, Xifeng
Koh, Woon-Puay
Bertazzi, Pier Alberto
Marchand, Loic Le
Bush, William S.
Tardón, Adonina
Rennert, Gad
Zhang, Ruyang
Teare, M. Dawn
Field, John K.
Lam, Stephen
Kiemeney, Lambertus A.
Saliba, Walid
Schabath, Matthew B.
Andrew, Angeline S.
Cox, Angela
Shen, Hongbing
Pesatori, Angela C.
Ye, Yuanqing
Muley, Thomas R.
Muller, David C.
Brhane, Yonathan
Leighl, Natasha
Shepherd, Frances A.
Johansen, Jakob S.
Haiman, Christopher A.
Wilkens, Lynne R.
Overvad, Kim
Fernández Somoano, Ana
Risch, Angela
Fernández Tardon, Guillermo
Janout, Vladimir
Heijden, Henricus F.M. van der
Kim, Jin Hee
Dai, Juncheng
Hu, Zhibin
Tsao, Ming-Sound
Taylor, Fiona
Davies, Michael PA
Marcus, Michael W.
Brunnström, Hans
Manjer, Jonas
Dunning, Alison
Rosenberger, Albert
Trichopoulou, Antonia
Tumino, Rosario
Doherty, Jennifer A.
Barnett, Matt P.
Arnold, Susanne M.
Chen, Chu
Goodman, Gary E.
Woll, Penella
SpiroMeta Consortium
Kontic, Milica
Bruske, Irene
Wichmann, H. Erich
Timens, Wim
Manz, Judith
Grankvist, Kjell
Johansson, Mikael
Rafnar, Thorunn
Gao, Yu-Tang
Haura, Eric B.
Bolca, Ciprian
Bierut, Laura J.
Holcatova, Ivana
Lissowska, Jolanta
Mukeria, Anush
Houlston, Richard S.
Ognjanovic, Simona
Thorgeirsson, Thorgeir E.
Orlowski, Tadeusz M.
Bickeböller, Heike
Scelo, Ghislaine
Swiatkowska, Beata
Zaridze, David
Bakke, Per
Spitz, Margaret R.
Zhu, Bin
Skaug, Vidar
Zienolddiny, Shanbeh
Duell, Eric J.
Butler, Lesley M.
Kamal, Ahsan
Albanes, Demetrius
McLaughlin, John
Stevens, Victoria L.
Joubert, Philippe
Lamontagne, Maxime
Gaddis, Nathan C.
Nickle, David C.
Obeidat, Ma’en
Song, Lei
Kachuri, Linda
Pikielny, Claudio
Soler Artigas, Maria
Tobin, Martin D.
Reginsson, Gunnar W.
Wain, Louise V.
Stefansson, Kari
Pooley, Karen A.
Lazarus, Philip
Hancock, Dana B.
Lutz, Sharon M.
Gu, Fangyi
Hong, Yun-Chul
Johnson, Eric O.
Zhu, Dakai
Qian, David C.
Lindströem, Sara
Keywords: Càncer de pulmó
Genòmica
Lung cancer
Genomics
Issue Date: 1-Jul-2017
Publisher: Springer Nature
Abstract: Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/ng.3892
It is part of: Nature Genetics, 2017, vol. 49, num. 7, p. 1126-1132
URI: http://hdl.handle.net/2445/124352
Related resource: https://doi.org/10.1038/ng.3892
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
McKayJD.pdf826.66 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.