Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/124352
Title: Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Author: McKay, James D.
Hung, Rayjean J.
Han, Younghun
Zong, Xuchen
Carreras Torres, Robert
Christiani, David C.
Caporaso, Neil E.
Johansson, Mattias
Xiao, Xiangjun
Li, Yafang
Byun, Jinyoung
Kachuri, Linda
Yuan, Jian-Min
Pikielny, Claudio
Wu, Xifeng
Soler Artigas, Maria
Tobin, Martin D.
Reginsson, Gunnar W.
Wain, Louise V.
Su, Li
Tyndale, Rachel F.
Rennert, Gad
Stefansson, Kari
Pooley, Karen A.
Lazarus, Philip
Hancock, Dana B.
Koh, Woon-Puay
Chanock, Stephen
Lutz, Sharon M.
Gu, Fangyi
Hong, Yun-Chul
Johnson, Eric O.
Risch, Angela
Haugen, Aage
Zhu, Dakai
Qian, David C.
Diao, Nancy
Lindström, Sara
Bertazzi, Pier Alberto
Chenevix-Trench, Georgia
Beesley, Jonathan
Mellemgaard, Anders
Bosse, Yohan
Zhang, Ruyang
Brennan, Paul
Landi, Maria Teresa
Fernández Somoano, Ana
Amos, Christopher I.
Liu, Geoffrey
Timofeeva, Maria N.
Hu, Zhibin
Bojesen, Stig E.
Marchand, Loic Le
Bush, William S.
Manjer, Jonas
Tardón, Adonina
Teare, M. Dawn
Field, John K.
Lam, Stephen
Kiemeney, Lambertus A. L. M.
Tsao, Ming-Sound
Saliba, Walid
Barnett, Matt P.
Schabath, Matthew B.
Andrew, Angeline S.
Cox, Angela
Shen, Hongbing
Dunning, Alison M.
Fernández Tardón, Guillermo
Pesatori, Angela Cecilia
Ye, Yuanqing
Muley, Thomas R.
Muller, David C.
Thorgeirsson, Thorgeir E.
Taylor, Fiona
Brhane, Yonathan
Leighl, Natasha
Shepherd, Frances A.
Johansen, Jakob S.
Rosenberger, Albert
Haiman, Christopher A.
Wilkens, Lynne R.
Janout, Vladimir
Overvad, Kim
Arnold, Susanne M.
Heijden, Henricus F.M. van der
Kim, Jin Hee
Ognjanovic, Simona
Dai, Juncheng
Davies, Michael P. A.
Marcus, Michael W.
Bakke, Per
Brunnström, Hans
Trichopoulou, Antonia
Tumino, Rosario
Butler, Lesley M.
Doherty, Jennifer Anne
Chen, Chu
Goodman, Gary E.
Woll, Penella
SpiroMeta Consortium
Spitz, Margaret R.
Kontic, Milica
Lamontagne, Maxime
Bruske, Irene
Wichmann, H.-Erich
Timens, Wim
Manz, Judith
Kamal, Ahsan
Orlowski, Tadeusz M.
Grankvist, Kjell
Johansson, Mikael B.
Rafnar, Thorunn
Gao, Yu-Tang
Melander, Olle
Zhu, Bin
Haura, Eric B.
Bolca, Ciprian
Bierut, Laura J.
Holcátová, Ivana
Albanes, Demetrius
Lissowska, Jolanta
Mukeria, Anush
Bickeböller, Heike
Houlston, Richard S.
Gaddis, Nathan C.
Scelo, Ghislaine
Swiatkowska, Beata
Jiang, Xia
Zaridze, David
Skaug, Vidar
Zienolddiny, Shanbeh
Aldrich, Melinda C.
Duell, Eric J.
McLaughlin, John R.
Stevens, Victoria L.
Ji, Xuemei
Joubert, Philippe
Nickle, David C.
Obeidat, Ma'en
Song, Lei
Keywords: Càncer de pulmó
Genòmica
Lung cancer
Genomics
Issue Date: 1-Jul-2017
Publisher: Springer Nature
Abstract: Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genomewide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/ng.3892
It is part of: Nature Genetics, 2017, vol. 49, num. 7, p. 1126-1132
URI: http://hdl.handle.net/2445/124352
Related resource: https://doi.org/10.1038/ng.3892
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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