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http://hdl.handle.net/2445/124399
Title: | Pre-clinical longitudinal monitoring of hemodynamic response to anti-vascular chemotherapy by hybrid diffuse optics |
Author: | Farzam, Parisa Johansson, Johannes D. Mireles, Miguel Jiménez Valerio, Gabriela Martínez Lozano, Mar Choe, Regine Casanovas i Casanovas, Oriol Durduran, Turgut |
Keywords: | Càncer de ronyó Tomografia òptica Renal cancer Optical tomography |
Issue Date: | 1-May-2017 |
Publisher: | Optical Society of America |
Abstract: | The longitudinal effect of an anti-vascular endothelial growth factor receptor 2 (VEGFR-2) antibody (DC 101) therapy on a xenografted renal cell carcinoma (RCC) mouse model was monitored using hybrid diffuse optics. Two groups of immunosuppressed male nude mice (seven treated, seven controls) were measured. Tumor microvascular blood flow, total hemoglobin concentration and blood oxygenation were investigated as potential biomarkers for the monitoring of the effect of therapy twice a week and were related to the final treatment outcome. These hemodynamic biomarkers have shown a clear differentiation between two groups by day four. Moreover, we have observed that pre-treatment values and early changes in hemodynamics are highly correlated with the therapeutic outcome demonstrating the potential of diffuse optics to predict the therapy response at an early time point. (C) 2017 Optical Society of America |
Note: | Reproducció del document publicat a: https://doi.org/10.1364/BOE.8.002563 |
It is part of: | Biomedical Optics Express, 2017, vol. 8, num. 5, p. 2563-2582 |
URI: | http://hdl.handle.net/2445/124399 |
Related resource: | https://doi.org/10.1364/BOE.8.002563 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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FarzamP.pdf | 3.66 MB | Adobe PDF | View/Open |
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