Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/124402
Title: Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Author: Phelan, Catherine M.
Kuchenbaecker, Karoline B.
Tyrer, Jonathan P.
Kar, Siddhartha P.
Lawrenson, Kate
Winham, Stacey J.
Dennis, Joe
Pirie, Ailith
Riggan, Marjorie
Chornokur, Ganna
Earp, Madalene A.
Garcia, Maria Jose
Olswold, Curtis
Domchek, Susan M.
Pugh, Elizabeth
Southey, Melissa C.
Chanock, Stephen J.
Pezzani, Lidia
Zorn, Kristin K.
Schmutzler, Rita Katharina
Phillips, Kelly-Anne
Bjorge, Line
Lissowska, Jolanta
Gerdes, Anne-Marie
Park-Simon, Tjoung-Won
Daly, Mary B.
Rodriguez Antona, Cristina
Huntsman, David G.
Schildkraut, Joellen M.
Niederacher, Dieter
Poole, Elizabeth M.
Haiman, Christopher A.
Jones, Michael E.
Ganz, Patricia A.
Pfeiler, Georg
Leminen, Arto
Aravantinos, Gerasimos
Dorfling, Cecilia M.
Chiquette, Jocelyne
van Nieuwenhuysen, Els
Ejlertsen, Bent
Garcia Barberan, Vanesa
Kobel, Martin
Frost, Debra
Rice, Patricia
Rappaport-Fuerhauser, Christine
Vijai, Joseph
Eng, Kevin H.
Hung, Jillian
Lilyquist, Jenna
Høgdall, Claus K.
Izatt, Louise
Hansen, Thomas V. O.
Lu, Karen H.
Luccarini, Craig
Weinberg, Clarice R.
Benitez, Javier
Borg, Åke
Karlan, Beth Y.
Bermisheva, Marina
Bodelon, Clara
Cramer, Daniel W.
Fridley, Brooke L.
Pearce, Celeste L.
Walker, Lisa
Olsson, Håkan
Carney, Michael E.
Aalfs, Cora M.
Chan, Salina B.
Huang, Ruea-Yea
Bogdanova, Natalia V.
Laitman, Yael
Tischkowitz, Marc
Kast, Karin
Lesueur, Fabienne
Izquierdo i Font, Àngel Xavier
Yannoukakos, Drakoulis
Damiola, Francesca
Montagna, Marco
Lundvall, Lene
Lee, Janet M.
Side, Lucy E.
Bonanni, Bernardo
Setiawan, V. Wendy
McGuire, Valerie
Engel, Christoph
Bruinsma, Fiona
Marchand, Loïc Le
Iversen, Edwin S.
Flanagan, James M.
Stadler, Zsofia
Hogervorst, Frans B. L.
Ramus, Susan J.
Teo, Soo-Hwang
Kiiski, Johanna I.
Hillemanns, Peter
Birrer, Michael J.
Fostira, Florentia
Sucheston-Campbell, Lara E.
Moes-Sosnowska, Joanna
Leroux, Dominique
Spurdle, Amanda B.
Jensen, Allan
Tworoger, Shelley S.
Wu, Xifeng
Hodgson, Shirley
Thomsen, Liv Cecilie Vestrheim
Chiew, Yoke-Eng
Caligo, Maria A.
Tihomirova, Laima
Prieur, Fabienne
Levine, Douglas A.
Swerdlow, Anthony J.
Friebel, Tara M.
Peixoto, Ana
Moysich, Kirsten B.
Conner, Thomas
Sieh, Weiva
Banerjee, Susana N.
Mendoza-Fandino, Gustavo A.
Lele, Shashikant B.
Thull, Darcy L.
Antonenkova, Natalia N.
Ferrer, Sandra Fert
Lee, Andrew
Soucy, Penny
Black, Amanda
Khusnutdinova, Elza
Leslie, Goska
Paul, James
van ensburg, Elizabeth J.
Heetvelde, Mattias Van
Bradbury, Angela R.
Kim, Sung-Won
Azzollini, Jacopo
Poppe, Bruce
Menon, Usha
Ness, Roberta B.
May, Taymaa
Prokofyeva, Darya
Buecher, Bruno
Ding, Yuan Chun
Goldgar, David E.
Ong, Kai-ren
Dork, Thilo
Giles, Graham G.
Hulick, Peter J.
Lázaro García, Conxi
Szafron, Lukasz
Brewer, Carole
Hein, Alexander
Ellis, Steve
Hildebrandt, Mat
Study EMBRACE
Glasspool, Rosalind
Peissel, Bernard
Monteiro, Alvaro N.
Onland-Moret, N. Charlotte
Piskorz, Anna M.
Neuhausen, Susan L.
Rothstein, Joseph H.
Sandler, Dale P.
Pujana Genestar, M. Ángel
Dao, Fanny
Bean, Yukie
Godwin, Andrew K.
Webb, Penelope M.
Richardson, Andrea
Kjaer, Susanne Krüger
Hahnen, Eric
Nedergaard, Lotte
Kwong, Ava
Hooning, Maartje J.
Merritt, Melissa A.
Cook, Linda S.
Risch, Harvey A.
Palli, Domenico
Meijers-Heijboer, Hanne
Coetzee, Simon
Lambrechts, Diether
Salvesen, Helga B.
Piedmonte, Marion
Pedersen, Inge Søkilde
Odunsi, Kunle
Antoniou, Antonis C.
Cescon, Terence
Meindl, Alfons
Offit, Kenneth
Høgdall, Estrid
Harrington, Patricia A.
Trichopoulou, Antonia
Poblete, Samantha R.
Amos, Christopher I.
Le, Nhu D.
Teixeira, Manuel R.
Schoemaker, Minouk J.
Doherty, Jennifer Anne
Wijnen, Juul
Foulkes, William D.
Radice, Paolo
Simard, Jacques
Ferguson, Sarah
Kupryjanczyk, Jolanta
Eilber, Ursula
Edwards, Todd
Huzarski, Tomasz
Orsulic, Sandra
Lyra, Paulo C.
Szabo, Csilla I.
Blankstein, Kenneth
Beesley, Jonathan
Papi, Laura
Fortner, Renée T.
Trabert, Britton
Romm, Jane
Shelford, Tameka
Rennert, Gad
Tung, Nadine
Håkansson, Niclas
Janavicius, Ramunas
Steinemann, Doris
Jensen, Uffe Birk
Liang, Dong
Karnezis, Anthony N.
Permuth, Jennifer B.
Campbell, Ian
Gore, Martin
Butzow, Ralf
Kiemeney, Lambertus A. L. M.
McNeish, Iain
Liebrich, Clemens
Tea, Muy-Kheng
Edwards, Digna Velez
Stoppa-Lyonnet, Dominique
Tognazzo, Silvia
Siddiqui, Nadeem
Vratimos, Athanassios
Wand, Dorothea
van Altena, Anne M.
Isaacs, Claudine
Lipworth, Loren
Brunet, Joan
Vanderstichele, Adriaan
Caldes, Trinidad
Mai, Phuong L.
Sharma, Priyanka
Peeters, Petra H. M.
Mitchell, Gillian
Anton-Culver, Hoda
Hosking, Karen
Sutphen, Rebecca
Rodriguez, Gustavo C.
Durst, Matthias
Olopade, Olufunmilayo I.
Walsh, Christine
Tinker, Anna V.
Tan, Yen Y.
Singer, Christian F.
Moffitt, Melissa
Gehrig, Andrea
Damirovna, Sakaeva Dina
Mensenkamp, Arjen R.
Mazoyer, Sylvie
Sellers, Thomas A.
Toland, Amanda Ewart
Claes, Kathleen B. M.
Peterlongo, Paolo
Kelemen, Linda E.
Wang-Gohrke, Shan
Jernetz, Mats
Díez Gibert, Orland
van der Hout, Annemarie H.
Dansonka-Mieszkowska, Agnieszka
Kruse, Torben A.
Lee, Jong Won
Kennedy, Catherine J.
Doheny, Kimberly F
Mulligan, Anna Marie
Sukiennicki, Grzegorz
Dossus, Laure
Henderson, Alex
Dworniczak, Bernd
Sutter, Christian
Lecarpentier, Julie
Goode, Ellen L.
Garber, Judy
Wentzensen, Nicolas
Barjhoux, Laure
Gayther, Simon A.
Manoukian, Siranoush
Larson, Melissa C.
Olah, Edith
Pocza, Timea
Andrulis, Irene L.
Terry, Kathryn L.
Harris, Holly R.
Lubinski, Jan
Hamann, Ute
Osorio, Ana
Robson, Mark
Park, Sue K.
Bojesen, Anders
Ziogas, Argyrios
Couch, Fergus J.
Whittemore, Alice
Brenton, James D.
Broberg, Per
Pharoah, Paul D. P.
Nathanson, Katherine L.
Porteous, Mary E.
Blok, Marinus J.
McGuffog, Lesley
Pujol, Pascal
Weitzel, Jeffrey N.
Taylor, Jack A.
Rudolph, Anja
Fasching, Peter A.
Modugno, Francesmary
Narod, Steven A.
Durán, Mercedes
Song, Honglin
Brinton, Louise A.
Hazelett, Dennis
Ottini, Laura
Wilkens, Lynne R.
Arun, Banu K.
Lester, Jenny
Dicks, Ed
Rookus, Matti A.
Rhiem, Kerstin
Berchuck, Andrew
Holland, Helene
Thompson, Pamela J.
Aloisio, Aimee A. D’
Brooks-Wilson, Angela R.
Nussbaum, Robert L.
James, Paul
Bernardini, Marcus Q.
Imyanitov, Evgeny N.
Cannioto, Rikki
Orr, Nicholas
Jakubowska, Anna
Senter, Leigha
Beckmann, Matthias W.
John, Esther M.
McLaughlin, John R.
Kannisto, Päivi
Easton, Douglas F.
Ekici, Arif B.
Larrañaga, Nerea
Aben, Katja K.
Fountzilas, George
Yang, Hannah
Rantala, Johanna
Pelttari, Liisa M.
Sobol, Hagay
Tone, Alicia
Evans, D. Gareth
Beeghly-Fadiel, Alicia
McAlpine, Jessica N.
Massuger, Leon F. A. G.
Rossing, Mary Anne
Adams, Marcia
Cunningham, Julie M.
Glendon, Gord
Chen, Xiao Qing
Defazio, Anna
Buys, Saundra S.
Goranova, Teodora
Gronwald, Jacek
Severi, Gianluca
Travis, Ruth C.
Vierkant, Robert A.
Eccles, Diana
van den Berg, David Berg, David
Varon-Mateeva, Raymonda
Goodman, Marc T.
Barkardottir, Rosa B.
Kopperud, Reidun K.
Runnebaum, Ingo B.
Johnatty, Sharon
Woo, Michelle
Greene, Mark H.
Wu, Anna H.
Cook, Jackie
Ana, Vega
Fogarty, Zachary C.
Pike, Malcolm C.
Eeles, Rosalind A.
Gentry-Maharaj, Aleksandra
Delnatte, Capucine
Milne, Roger L.
Thomassen, Mads
Hunter, David J.
Gruber, Stephen B.
Arver, Brita
Nevanlinna, Heli
Vergote, Ignace
Musinsky, Jacob
Hauke, Jan
Adlard, Julian
Wappenschmidt, Barbara
Friedman, Eitan
Davidson, Rosemarie
Arnold, Norbert
O'Malley, David M.
Chung, Wendy K.
Barrowdale, Daniel
Pejovic, Tanja
Elvira, Mingajeva
Chang-Claude, Jenny
van der Luijt, Rob B.
Balmaña, Judith
Wolk, Alicja
Chenevix-Trench, Georgia
Keywords: Càncer d'ovari
Ovarian cancer
Issue Date: 1-May-2017
Publisher: Nature Publishing
Abstract: To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/ng.3826
It is part of: Nature Genetics, 2017, vol. 49, num. 5, p. 680-691
URI: http://hdl.handle.net/2445/124402
Related resource: https://doi.org/10.1038/ng.3826
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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