Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/124402
Title: Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer
Author: Phelan, Catherine M.
Kuchenbaecker, Karoline B.
Tyrer, Jonathan P.
Kar, Siddhartha P.
Lawrenson, Kate
Winham, Stacey J.
Dennis, Joe
Pirie, Ailith
Riggan, Marjorie
Chornokur, Ganna
Earp, Madalene A.
Caldes, Trinidad
Szabo, Csilla I.
Aalfs, Cora M.
Park-Simon, Tjoung-Won
Friebel, Tara M.
Odunsi, Kunle
Huntsman, David G.
Caligo, Maria A.
Garber, Judy
Menon, Usha
Kjaer, Susanne K.
Kast, Karin
Dao, Fanny
Lázaro García, Conxi
Duran, Mercedes
Ana, Vega
Imyanitov, Evgeny N.
Campbell, Ian
Thull, Darcy L.
Kannisto, Päivi
Ramus, Susan J.
Paul, James
Chen, Xiao Qing
Tea, Muy-Kheng
Ejlertsen, Bent
Arun, Banu K.
Vergote, Ignace
Sucheston-Campbell, Lara E.
Cannioto, Rikki
Travis, Ruth C.
Pedersen, Inge Søkilde
Kopperud, Reidun K.
Greene, Mark H.
Wu, Anna H.
Adlard, Julian
Davidson, Rosemarie
Olopade, Olufunmilayo I.
Peixoto, Ana
Prokofyeva, Darya
Lee, Andrew
Hahnen, Eric
Coetzee, Simon
Edwards, Digna Velez
Bean, Yukie
Peeters, Petra H. M.
Kupryjanczyk, Jolanta
Dicks, Ed
Defazio, Anna
Trichopoulou, Antonia
Delnatte, Capucine
Chung, Wendy K.
Chenevix-Trench, Georgia
Garcia, María J.
Pugh, Elizabeth
Daly, Mary B.
Chiquette, Jocelyne
Garcia Barberan, Vanesa
Larson, Melissa C.
Arver, Brita
Bradbury, Angela R.
Yannoukakos, Drakoulis
Rothstein, Joseph H.
Lundvall, Lene
Huzarski, Tomasz
Håkansson, Niclas
Jensen, Allan
Gehrig, Andrea
Foulkes, William D.
Mendoza-Fandiño, Gustavo
Henderson, Alex
Barkardottir, Rosa B.
Brewer, Carole
Lecarpentier, Julie
Marchand, Loic Le
Gentry-Maharaj, Aleksandra
Vierkant, Robert A.
Wijnen, Juul
Gerdes, Anne-Marie
Eng, Kevin H.
Bodelon, Clara
Hamann, Ute
Sandler, Dale P.
Meijers-Heijboer, Hanne
Jensen, Uffe Birk
Goode, Ellen L.
Andrulis, Irene L.
Elvira, Mingajeva
Schmutzler, Rita Katharina
Hansen, Thomas V. O.
McGuffog, Lesley
Schildkraut, Joellen M.
Ellis, Steve
Swerdlow, Anthony J.
Le, Nhu D.
Singer, Christian F.
Moysich, Kirsten B.
Harrington, Patricia A.
Leminen, Arto
Romm, Jane
Onland-Moret, N. Charlotte
Isaacs, Claudine
Permuth, Jennifer B.
Johnatty, Sharon
Bogdanova, Natalia
Musinsky, Jacob
Harris, Holly R.
Simard, Jacques
Malley, David M. O’
Cook, Linda S.
Høgdall, Claus K.
Park, Sue K.
Khusnutdinova, Elza
Fogarty, Zachary C.
Bonanni, Bernardo
Zorn, Kristin K.
Hauke, Jan
Benitez, Javier
Tan, Yen Y.
Pearce, Celeste L.
Chan, Salina B.
Engel, Christoph
Iversen, Edwin S.
Song, Honglin
Teixeira, Manuel R.
Tung, Nadine
Eilber, Ursula
Mai, Phuong L.
Durst, Matthias
Bojesen, Anders
Taylor, Jack A.
Lee, Jong Won
Eeles, Ros
Izatt, Louise
Sellers, Thomas A.
Izquierdo i Font, Àngel Xavier
Hogervorst, Frans B. L.
Moes-Sosnowska, Joanna
Leroux, Dominique
Tworoger, Shelley S.
Soucy, Penny
Leslie, Goska
Pelttari, Liisa M.
Lee, Janet M.
Beesley, Jonathan
Chanock, Stephen
Vratimos, Athanassios
Pujana Genestar, M. Ángel
Mulligan, Anna Marie
Manoukian, Siranoush
Lester, Jenny
Diez, Orland
Radice, Paolo
Mclaughlin, John R.
Fridley, Brooke L.
Gore, Martin
Ekici, Arif B.
Pezzani, Lidia
Lesueur, Fabienne
Borg, Åke
Levine, Douglas A.
Kim, Sung-Won
Giles, Graham G.
Massuger, Leon F. A. G.
Wand, Dorothea
Rodriguez, Gustavo C.
Olah, Edith
Larrañaga, Nerea
Evans, D. Gareth
Kiiski, Johanna I.
May, Taymaa
Eccles, Diana
Conner, Thomas
Kiemeney, Lambertus A.
Amos, Christopher I.
Peterlongo, Paolo
Wilkens, Lynne R.
Schoemaker, Minouk J.
Mazoyer, Sylvie
Antonenkova, Natalia
Stoppa-Lyonnet, Dominique
Nathanson, Katherine L.
Terry, Kathryn L.
Olsson, Håkan
Glasspool, Rosalind
Setiawan, V. Wendy
McAlpine, Jessica N.
Dansonka-Mieszkowska, Agnieszka
Stadler, Zsofia
Hosking, Karen
Cunningham, Julie M.
Orsulic, Sandra
Laitman, Yael
Godwin, Andrew K.
Chiew, Yoke-Eng
McGuire, Valerie
Ding, Yuan Chun
Ottini, Laura
Szafron, Lukasz
Hildebrandt, Mat
Nedergaard, Lotte
Woo, Michelle
Kelemen, Linda E.
Gayther, Simon A.
Kennedy, Catherine J.
Pujol, Pascal
Jones, Michael E.
Glendon, Gord
Goodman, Marc T.
Pfeiler, Georg
Ness, Roberta B.
Ganz, Patricia A.
Neuhausen, Susan L.
Merritt, Melissa A.
Salvesen, Helga B.
Piedmonte, Marion
Antoniou, Antonis C.
Edwards, Todd
Lyra, Paulo C.
Balmana, Judith
Dworniczak, Bernd
Hodgson,Shirley
Brenton, James D.
Altena, Anne M. van
Senter, Leigha
Rantala, Johanna
Pike, Malcolm C.
James, Paul
Hout, Annemarie H. van der
Arnold, Norbert
Lubinski, Jan
Barrowdale, Daniel
Thomsen, Liv Cecilie Vestrheim
Piskorz, Anna M.
Goldgar, David E.
Poblete, Samantha R.
Papi, Laura
Liang, Dong
Rappaport-Fuerhauser, Christine
Broberg, Per
Sobol, Hagay
Pejovic, Tanja
Kobel, Martin
Palli, Domenico
Rennert, Gad
Karlan, Beth Y.
Doherty, Jennifer Anne
Osorio, Ana
Claes, Kathleen B. M.
Thompson, Pamela J.
Wang-Gohrke, Shan
Rhiem, Kerstin
Ferguson, Sarah
Ziogas, Argyrios
Severi, Gianluca
Beeghly-Fadiel, Alicia
Southey, Melissa C.
Liebrich, Clemens
Webb, Penelope M.
Rice, Patricia
Hooning, Maartje J.
Modugno, Francesmary
Hung, Jillian
Sukiennicki, Grzegorz
Peissel, Bernard
Lipworth, Loren
Høgdall, Estrid
Richardson, Andrea
Janavicius, Ramunas
Cook, Jackie
McNeish, Iain
Sharma, Priyanka
Carney, Michael E.
Aloisio, Aimee A. D’
Yang, Hannah
Orr, Nicholas
Berg, David Van Den
Olswold, Curtis
Lilyquist, Jenna
Cramer, Daniel W.
Shelford, Tameka
Lele, Shashikant B.
Siddiqui, Nadeem
Anton-Culver, Hoda
Walsh, Christine
Tinker, Anna V.
Moffitt, Melissa
Doheny, Kimberly F
Dossus, Laure
Fostira, Florentia
Meindl, Alfons
Goranova, Teodora
Pharoah, Paul D. P.
Wappenschmidt, Barbara
Luijt, Rob B. van der
Tischkowitz, Marc
Nevanlinna, Heli
Bernardini, Marcus Q.
Flanagan, James M.
Aravantinos, Gerasimos
Offit, Kenneth
Tognazzo, Silvia
Lissowska, Jolanta
Toland, Amanda Ewart
Sutter, Christian
Pocza, Timea
Heetvelde, Mattias Van
Gronwald, Jacek
Wolk, Alicja
Teo, Soo-Hwang
Sutphen, Rebecca
Barjhoux, Laure
Ong, Kai-ren
Jernetz, Mats
Rossing, Mary Anne
Holland, Helene
Thomassen, Mads
Brooks-Wilson, Angela
Nieuwenhuysen, Els Van
Kruse, Torben A.
Weinberg, Clarice R.
Frost, Debra
Wu, Xifeng
Poole, Elizabeth M.
Brunet, Joan
Rensburg, Elizabeth J. van
Mitchell, Gillian
Runnebaum, Ingo B.
Azzollini, Jacopo
Beckmann, Matthias W.
Porteous, Mary E.
Mensenkamp, Arjen R.
Vanderstichele, Adriaan
Niederacher, Dieter
Huang, Ruea-Yea
Robson, Mark
Weitzel, Jeffrey N.
Hein, Alexander
Hunter, David J.
Chang-Claude, Jenny
Bermisheva, Marina
Spurdle, Amanda B.
Poppe, Bruce
Hulick, Peter J.
Wentzensen, Nicolas
Phillips, Kelly-Anne
Whittemore, Alice
Fasching, Peter A.
Brinton, Louise
Hazelett, Dennis
Jakubowska, Anna
John, Esther M.
Lambrechts, Diether
Rodriguez-Antona, Cristina
Lu, Karen H.
Dorfling, Cecilia M.
Bruinsma, Fiona
Birrer, Michael J.
Monteiro, Alvaro N.
Side, Lucy E.
Kwong, Ava
Ferrer, Sandra Fert
Damirovna, Sakaeva Dina
Couch, Fergus J.
Prieur, Fabienne
Berchuck, Andrew
Easton, Douglas F.
Tone, Alicia
Bjorge, Line
Luccarini, Craig
Risch, Harvey A.
Narod, Steven A.
Fountzilas, George
Steinemann, Doris
Nussbaum, Robert L.
Vijai, Joseph
Milne, Roger L.
Damiola, Francesca
Gruber, Stephen
Black, Amanda
Buecher, Bruno
Domchek, Susan M.
Cescon, Terence
Banerjee, Susana N.
Haiman, Christopher A.
Blankstein, Kenneth
Rudolph, Anja
Walker, Lisa
Fortner, Renée T.
Friedman, Eitan
Rookus, Matti A.
Blok, Marinus J.
Sieh, Weiva
Study EMBRACE
Adams, Marcia
Varon-Mateeva, Raymonda
Butzow, Ralf
Montagna, Marco
Hillemanns, Peter
Dork, Thilo
Trabert, Britton
Karnezis, Anthony
Aben, Katja K.
Tihomirova, Laima
Buys, Saundra S.
Keywords: Càncer d'ovari
Ovarian cancer
Issue Date: 1-May-2017
Publisher: Nature Publishing
Abstract: To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/ng.3826
It is part of: Nature Genetics, 2017, vol. 49, num. 5, p. 680-691
URI: http://hdl.handle.net/2445/124402
Related resource: https://doi.org/10.1038/ng.3826
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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