Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/124413
Title: | Genetic And Epigenetic Determinants In Autoinflammatory Diseases |
Author: | Álvarez Errico, Damiana Vento Tormo, Roser Ballestar Tarín, Esteban |
Keywords: | Epigenètica Inflamació Epigenetics Inflammation |
Issue Date: | 22-Mar-2017 |
Publisher: | Frontiers Media |
Abstract: | The concept of autoinflammation has evolved over the past 20 years, beginning with the discovery that mutations in the Mediterranean Fever (MEFV) gene were causative of Familial Mediterranean Fever. Currently, autoinflammatory diseases comprise a wide range of disorders with the common features of recurrent fever attacks, prevalence of hyperreactive innate immune cells, and signs of inflammation that can be systemic or organ specific in the absence of pathogenic infection of autoimmunity. Innate immune cells from the myeloid compartment are the main effectors of uncontrolled inflammation that is caused in great extent by the overproduction of inflammatory cytokines such as IL-1 beta and IL-18. Defects in several signaling pathways that control innate immune defense, particularly the hyperreactivity of one or more inflammasomes, are at the core of pathologic autoinflammatory phenotypes. Although many of the autoinflammatory syndromes are known to be monogenic, some of them are genetically complex and are impacted by environmental factors. Recently, epigenetic dysregulation has surfaced as an additional contributor to pathogenesis. In the present review, we discuss data that are currently available to describe the contribution of epigenetic mechanisms in autoinflammatory diseases. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2017.00318 |
It is part of: | Frontiers in Immunology, 2017, vol. 8 |
URI: | http://hdl.handle.net/2445/124413 |
Related resource: | https://doi.org/10.3389/fimmu.2017.00318 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Alvarez-ErricoD.pdf | 4.25 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License