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Title: Hydraulic fracturing in cells and tissues: fracking meets cell biology
Author: Arroyo, Marino
Trepat Guixer, Xavier
Keywords: Fisiologia humana
Membranes cel·lulars
Teixits (Histologia)
Human physiology
Cell membranes
Issue Date: 28-Feb-2017
Publisher: Elsevier Ltd
Abstract: The animal body is largely made of water. A small fraction of body water is freely flowing in blood and lymph, but most of it is trapped in hydrogels such as the extracellular matrix (ECM), the cytoskeleton, and chromatin. Besides providing a medium for biological molecules to diffuse, water trapped in hydrogels plays a fundamental mechanical role. This role is well captured by the theory of poroelasticity, which explains how any deformation applied to a hydrogel causes pressure gradients and water flows, much like compressing a sponge squeezes water out of it. Here we review recent evidence that poroelastic pressures and flows can fracture essential biological barriers such as the nuclear envelope, the cellular cortex, and epithelial layers. This type of fracture is known in engineering literature as hydraulic fracturing or 'fracking'.
Note: Versió postprint del document publicat a:
It is part of: Current Opinion in Cell Biology, 2017, vol. 44, num. 2, p. 1-6
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ISSN: 0955-0674
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Biomedicina)

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