Title: | European contribution to the study of ROS: A summary of the findings and
prospects for the future from the COST action BM1203 (EU-ROS) |
Author: | Egea, Javier Fabregat Romero, Isabel Frapart, Yves M. Ghezzi, Pietro Görlach, Agnes Kietzmann, Thomas Kubaichuk, Kateryna Knaus, Ulla G. Lopez, Manuela G. Olaso Gonzalez, Gloria Petry, Andreas Krieg, Thomas Laranjinha, João Lazou, Antigone Smith, Geoffrey L. Li, Huige Valentová, Kateřina Peyrot, Fabienne Martínez Ruiz, Antonio Matsui, Reiko McBean, Gethin J. Steinbrenner, Holger Meredith, Stuart P. Robledinos Antón, Natalia Miranda Vizuete, Antonio Messens, Joris Phylactides, Marios Mojović, Miloš Münzel, Thomas Soldati, Thierry Schulz, Rainer Muzykantov, Vladimir Stepanić, Višnja Nguyen, Isabel T.N. Oelze, Matthias Oliveira, Nuno G. Žarković, Neven Palmeira, Carlos M. Sousa, Bebiana C. Pircalabioru, Gratiela G. Papaevgeniou, Nikoletta Pitt, Andrew R. Poulsen, Henrik E. Steven, Sebastian Rodríguez Mañas, Leocadio Breusegem, Frank Van Spickett, Corinne M. Rolo, Anabela P. Zatloukalová, Martina Rousset, Francis Ruskovska, Tatjana Saraiva, Nuno Antelmann, Haike Sasson, Shlomo Chondrogianni, Niki Varisli, Lokman Schröder, Katrin Semen, Khrystyna Seredenina, Tamara Shakirzyanova, Anastasia Zielonka, Jacek Stancic, Ana Vina, Jose Veal, Elizabeth A. Stasia, Marie José Tokatlidis, Kostas Antunes, Fernando Förstermann, Ulrich Winyard, Paul Tuncay, Erkan Turan, Belma Ursini, Fulvio Smet, Barbara De Vacek, Jan Aslan, Mutay Yalçın, A. Suha Vajnerova, Olga Abbas, Kahina Yelisyeyeva, Olha Touyz, Rhian M. Conrad, Marcus Bachschmid, Markus M. Papapetropoulos, Andreas Debelec-Butuner, Bilge Grune, Tilman Lamas, Santiago Schmidt, Harald H. H. W. Herget, Jan Lisa, Fabio Di Cooke, Marcus S. Ademowo, Opeyemi S. Daiber, Andreas Afonso, Catarina B. Andreadou, Ioanna Dias, Irundika H.K. Barbosa, Rui M. Giniatullin, Rashid Costa, João G. Belousov, Vsevolod Hernansanz Agustín, Pablo Berndt, Carsten Bernlohr, David Bertran Rodríguez, Esther Korac, Bato Bindoli, Alberto Miguel, Verónica Giricz, Zoltán Bottari, Serge P. Brito, Paula M. Carrara, Guia Casas, Ana I. Hillion, Melanie Cuadrado, Antonio Chatzi, Afroditi Görbe, Anikó Dang, Pham My-Chan Dunn, Joe Dan Korkmaz, Kemal Sami Pavicevic, A Edson, Amanda J. Assar, Mariam El El-Benna, Jamel Ferdinandy, Péter Monsalve, María Fernandes, Ana S. Koziel, Rafal Griffiths, Helen Fladmark, Kari E. Hampl, Vaclav Hanf, Alina Huang, Jingjing Mikhed, Yuliya Kračun, Damir Ilikay, Serap Mouthuy, Pierre-Alexis Jansen-durr, P Jaquet, Vincent Joles, Jaap A. Prieto, Ignacio Kalyanaraman, Balaraman Milisav, Irina Kaminskyy, Danylo Karbaschi, Mahsa Kleanthous, Marina Klotz, Lars-Oliver Mulvey, John Krause, Karl-Heinz Pedre, Brandán Milković, Lidija Křen, Vladimír Rigobello, Maria Pia |
Keywords: | Estrès oxidatiu Antioxidants Oxidative stress |
Issue Date: | 1-Oct-2017 |
Publisher: | Elsevier Science |
Abstract: | The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated to providing new insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. This report highlights the major achievements of EU-ROS as well as research updates and new perspectives arising from its members. The EU-ROS consortium comprised more than 140 active members who worked together for four years on the topics briefly described below. The formation of reactive oxygen and nitrogen species (RONS) is an established hallmark of our aerobic environment and metabolism but RONS also act as messengers via redox regulation of essential cellular processes. The fact that many diseases have been found to be associated with oxidative stress established the theory of oxidative stress as a trigger of diseases that can be corrected by antioxidant therapy. However, while experimental studies support this thesis, clinical studies still generate controversial results, due to complex pathophysiology of oxidative stress in humans. For future improvement of antioxidant therapy and better understanding of redox-associated disease progression detailed knowledge on the sources and targets of RONS formation and discrimination of their detrimental or beneficial roles is required. In order to advance this important area of biology and medicine, highly synergistic approaches combining a variety of diverse and contrasting disciplines are needed. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.redox.2017.05.007 |
It is part of: | Redox Biology, 2017, vol. 13, p. 94-162 |
URI: | http://hdl.handle.net/2445/124464 |
Related resource: | https://doi.org/10.1016/j.redox.2017.05.007 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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