Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/124465
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Andrés Benito, Pol | - |
dc.contributor.author | Moreno Castro, Jesús | - |
dc.contributor.author | Aso Pérez, Ester | - |
dc.contributor.author | Povedano, Mònica | - |
dc.contributor.author | Ferrer, Isidro (Ferrer Abizanda) | - |
dc.date.accessioned | 2018-09-12T09:58:10Z | - |
dc.date.available | 2018-09-12T09:58:10Z | - |
dc.date.issued | 2017-03-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/124465 | - |
dc.description.abstract | Transcriptome arrays identifies 747 genes differentially expressed in the anterior horn of the spinal cord and 2,300 genes differentially expressed in frontal cortex area 8 in a single group of typical sALS cases without frontotemporal dementia compared with age-matched controls. Main up-regulated clusters in the anterior horn are related to inflammation and apoptosis; down-regulated clusters are linked to axoneme structures and protein synthesis. In contrast, up-regulated gene clusters in frontal cortex area 8 involve neurotransmission, synaptic proteins and vesicle trafficking, whereas main down-regulated genes cluster into oligodendrocyte function and myelin-related proteins. RT-qPCR validates the expression of 58 of 66 assessed genes from different clusters. The present results: a. reveal regional differences in de-regulated gene expression between the anterior horn of the spinal cord and frontal cortex area 8 in the same individuals suffering from sALS; b. validate and extend our knowledge about the complexity of the inflammatory response in the anterior horn of the spinal cord; and c. identify for the first time extensive gene up-regulation of neurotransmission and synaptic-related genes, together with significant down-regulation of oligodendrocyte-and myelin-related genes, as important contributors to the pathogenesis of frontal cortex alterations in the sALS/frontotemporal lobar degeneration spectrum complex at stages with no apparent cognitive impairment. | - |
dc.format.extent | 29 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Impact Journals | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.18632/aging.101195 | - |
dc.relation.ispartof | Aging, 2017, vol. 9, num. 3, P. 823-851 | - |
dc.relation.uri | https://doi.org/10.18632/aging.101195 | - |
dc.rights | cc by (c) Andrés Benito et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.classification | Esclerosi lateral amiotròfica | - |
dc.subject.other | Gene expression | - |
dc.subject.other | Amyotrophic lateral sclerosis | - |
dc.title | Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 686635 | - |
dc.date.updated | 2018-07-24T12:10:22Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28283675 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Patologia i Terapèutica Experimental) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
686635.pdf | 2.47 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License