Please use this identifier to cite or link to this item:
Title: Human Papillomavirus Infection in HIV-1 Infected Women in Catalonia (Spain): Implications for Prevention of Cervical Cancer
Author: Stuardo, Valeria
Agustí, Cristina
Godínez, José M.
Montoliu, Alexandra
Torné Bladé, Aureli
Tarrats, Antoni
Alcalde, Carme
Martín, Dolores
Fernández Montolí, Ma. Eulalia
Vanrell, Cristina
Solé, Josefa
Canet, Yolanda
Marqueta, José M.
Mohamed, Jadiyettu
Cuenca, Isabel
Loncá, Montserrat
Sirera, Guillem
Ferrer, Elena
Domingo, Pere (Domingo Pedrol)
Lloveras Rubio, Betlem
Miró Meda, José M.
Sanjosé Llongueras, Silvia de
Casabona, Jordi
Keywords: Papil·lomavirus
Càncer de coll uterí
Medicina preventiva
VIH (Virus)
Cervix cancer
Preventive medicine
HIV (Viruses)
Issue Date: 30-Oct-2012
Publisher: Public Library of Science (PLoS)
Abstract: Background High-risk human Papillomavirus infection is a necessary factor for cervical squamous intraepithelial lesions and invasive cervical cancer. In HIV-1-infected women, HPV infection is more prevalent and a higher risk of cervical cancer has been identified. We aimed to calculate the prevalence of infection by HR-HPV, determine the factors associated with this infection and abnormal cytology findings and to describe the history of cervical cancer screening in HIV-1-infected women. Methods We enrolled 479 HIV-1-infected women from the PISCIS cohort. Each patient underwent a gynecological check-up, PAP smear, HPV AND Hybrid capture, HPV genotyping, and colposcopy and biopsy, if necessary. We applied questionnaires to obtain information on sociodemographic, behavioral, clinical, and cervical screening variables. We present a cross-sectional analysis. Results Median age was 42 years. The prevalence of HR-HPV infection was 33.2% and that of high-grade squamous intraepithelial lesions (HSIL) was 3.8%. The most common genotypes were 16(23%), 53(20.3%), and 52(16.2%). The factor associated with HR-HPV infection was age <30 years (odds ratio[OR],2.5; 95%confidence interval[CI],1.1-5.6). The factors associated with the presence of HSIL or low-grade squamous intraepithelial lesions (LSIL) were CD4T-lymphocyte count <200cells/mm3 versus >500cells/mm3 (OR,8.4; 95%CI,3.7-19.2), HIV-1 viral load >10,000copies/mL versus <400copies/mL (OR,2.1; 95%CI,1.0-4.4), and use of oral contraceptives (OR,2.0; 95%CI,1.0-3.9). Sixty percent of HIV-1-infected women had had one Pap smear within the last 2 years. Conclusions The high prevalence of HPV infection and cervical lesions in the HIV-1-infected population in Catalonia, as well as the low coverage and frequency of screening in this group, means that better preventive efforts are necessary and should include vaccination against HPV, better accessibility to screening programs, training of health care professionals, and specific health education for HIV-1-infected women.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2012, vol. 7, num. 10, p. e47755
Related resource:
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
639873.pdf245.58 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons