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Title: | Relationship between the use of inhaled steroids for chronic respiratory diseases and early outcomes in community-acquired pneumonia. |
Author: | Almirall, Jordi Bolibar, Ignasi Serra Prat, Mateu Palomera Fanegas, Elisabet Roig, Jordi Hospital, Imma Carandell, Eugenia Agustí, Mercè Ayuso, Pilar Estela, Andreu Torres Martí, Antoni Community-Acquired Pneumonia in Catalan Countries |
Keywords: | Pneumònia adquirida a la comunitat Salut pública Esteroides Malalties del pulmó Community-acquired pneumonia Public health Steroids Pulmonary diseases |
Issue Date: | 5-Sep-2013 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Background The role of inhaled steroids in patients with chronic respiratory diseases is a matter of debate due to the potential effect on the development and prognosis of community-acquired pneumonia (CAP). We assessed whether treatment with inhaled steroids in patients with chronic bronchitis, COPD or asthma and CAP may affect early outcome of the acute pneumonic episode. Methods Over 1-year period, all population-based cases of CAP in patients with chronic bronchitis, COPD or asthma were registered. Use of inhaled steroids were registered and patients were followed up to 30 days after diagnosis to assess severity of CAP and clinical course (hospital admission, ICU admission and mortality). Results Of 473 patients who fulfilled the selection criteria, inhaled steroids were regularly used by 109 (23%). In the overall sample, inhaled steroids were associated with a higher risk of hospitalization (OR=1.96, p = 0.002) in the bivariate analysis, but this effect disappeared after adjusting by other severity-related factors (adjusted OR=1.08, p=0.787). This effect on hospitalization also disappeared when considering only patients with asthma (OR=1.38, p=0.542), with COPD alone (OR=4.68, p=0.194), but a protective effect was observed in CB patients (OR=0.15, p=0.027). Inhaled steroids showed no association with ICU admission, days to clinical recovery and mortality in the overall sample and in any disease subgroup. Conclusions Treatment with inhaled steroids is not a prognostic factor in COPD and asthmatic patients with CAP, but could prevent hospitalization for CAP in patients with clinical criteria of chronic bronchitis. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0073271 |
It is part of: | PLoS One, 2013, vol. 8, num. 9, p. e73271 |
URI: | http://hdl.handle.net/2445/124731 |
Related resource: | https://doi.org/10.1371/journal.pone.0073271 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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