Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/124981
Title: Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples
Author: Castro Catala, Marta de
van Nierop, Martine
Barrantes Vidal, Neus
Cristóbal-Narváez, Paula
Sheinbaum, Tamara
Kwapil, Thomas R.
Peña, Elionora
Jacobs, Nele
Derom, Catherine
Thiery, Evert
van Os, Jim
van Winkel, Ruud
Rosa, Araceli
Keywords: Psicosi
Infància
Traumes psíquics
Psychoses
Childhood
Psychic trauma
Issue Date: Dec-2016
Publisher: Elsevier Ltd
Abstract: Childhood trauma exposure is a robust environmental risk factor for psychosis. However, not all exposed individuals develop psychotic symptoms later in life. The Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been suggested to moderate the psychosis-inducing effects of childhood trauma in clinical and nonclinical samples. Our study aimed to explore the interaction effect between childhood trauma and the BDNF Val66Met polymorphism on subclinical psychotic experiences (PEs). This was explored in two nonclinical independent samples: an undergraduate and technical-training school student sample (n = 808, sample 1) and a female twin sample (n = 621, sample 2). Results showed that childhood trauma was strongly associated with positive and negative PEs in nonclinical individuals. A BDNF Val66Met x childhood trauma effect on positive PEs was observed in both samples. These results were discordant in terms of risk allele: while in sample 1 Val allele carriers, especially males, were more vulnerable to the effects of childhood trauma regarding PEs, in sample 2 Met carriers presented higher PEs scores when exposed to childhood trauma, compared with Val carriers. Moreover, in sample 2, a significant interaction was also found in relation to negative PEs. Our study partially replicates previous findings and suggests that some individuals are more prone to develop PEs following childhood trauma because of a complex combination of multiple factors. Further studies including genetic, environmental and epigenetic factors may provide insights in this field.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.jpsychires.2016.08.014
It is part of: Journal of Psychiatric Research, 2016, vol. 83, p. 121-129
URI: http://hdl.handle.net/2445/124981
Related resource: https://doi.org/10.1016/j.jpsychires.2016.08.014
ISSN: 0022-3956
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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