Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/125248
Title: Colorectal cancer, sun exposure and dietary vitamin D and calcium intake in the MCC-Spain study
Author: Vallès, Xavier
Alonso Aguado, Maria Henar
López Caleya, Juan Francisco
Díez Obrero, Virginia
Dierssen Sotos, Trinidad
Lope, Virginia
Molina Barceló, Ana
Chirlaque, María Dolores
Jiménez Moleón, José Juan
Fernández Tardón, Guillermo
Castilla, Jesús
Amiano, Pilar
Capelo, Rocío
Castaño-Vinyals, Gemma
Guinó, Elisabet
Molina de la Torre, Antonio José
Moreno Iribas, Conchi
Pérez Gómez, Beatriz
Aragonès Sanz, Núria
Llorca Díaz, Javier
Martín Sánchez, Vicente
Kogevinas, Manolis
Pollán, Marina
Moreno Aguado, Víctor
Keywords: Càncer colorectal
Vitamina D
Calci
Colorectal cancer
Vitamin D
Calcium
Issue Date: 25-Sep-2018
Publisher: Elsevier
Abstract: Objectives: To explore the association of colorectal cancer with environmental solar radiation and sun exposure behavior, considering phenotypic variables (eye color, hair color and skin phenotype), dietary intake of vitamin D and calcium, and socio-demographic factors. Study design: Multicenter population-based frequency matched case-control study in Spain (MCC-Spain), with 2140 CRC cases and 3950 controls. Methods: Data were obtained through personal interviews using a structured epidemiological questionnaire that included socio-demographic data, residential history, environmental exposures, behavior, phenotypic and dietary information. An environmental-lifetime sun exposure score was constructed combining residential history and average daily solar radiation, direct and diffuse. Logistic regression was used to explore the association between different variables. A structural equation model was used to verify the associations of the conceptual model. Results: We found a lower risk of CRC in subjects frequently exposed to sunlight during the previous summer and skin burning due to sun exposure. No association was observed in relation to the residential solar radiation scores. Subjects with light eye or light hair colors had a lower risk of CRC that those with darker colors. Dietary calcium and vitamin D were also protective factors, but not in the multivariate model. The structural equation model analysis suggested that higher sun exposure was associated with a decreased risk of CRC, as well as dietary intake of calcium and vitamin D, and these factors are correlated among themselves and with environmental solar radiation and skin phenotypes. Conclusion: The results agree with previous observations that sun exposure, dietary vitamin D and calcium intake, and serum 25(OH)D concentration reduce the risk of CRC and indicate that these factors may be relevant for cancer prevention.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.envint.2018.09.030
It is part of: Environment International, 2018, vol. 121(1), p. 428-434
URI: http://hdl.handle.net/2445/125248
Related resource: https://doi.org/10.1016/j.envint.2018.09.030
ISSN: 0160-4120
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
Article_EI_180917-postprint.pdf415.7 kBAdobe PDFView/Open    Request a copy


Embargat   Document embargat fins el 25-9-2020


This item is licensed under a Creative Commons License Creative Commons