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Title: | Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients |
Author: | Fernández, Belén Ferrer, Isidro (Ferrer Abizanda) Gil, Fernando Hilfiker, Sabine |
Keywords: | Cervell Ferro Demència amb cossos de Lewy Malaltia de Parkinson Brain Iron Lewy body dementia Parkinson's disease |
Issue Date: | 1-Jan-2017 |
Publisher: | Elsevier |
Abstract: | Iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of Parkinsons disease (PD) patients as compared to controls, which correlates with motor disability. Here, we have analyzed total iron levels in cells as well as mouse and human brain samples by atomic absorption spectroscopy (AAS). Our data indicate that iron load is more pronounced in cells with dopaminergic features. Moreover, region-specific differences in iron load reflecting those in the human brain were detected in rodent brains as well. Whilst altered iron load was not observed in other regions also affected in PD patients, we report a significant increase in iron load in the SN of Lewy body disease patients as compared to Alzheimers disease (AD) patients or controls, which correlates with neurodegeneration in this brain area. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.toxrep.2017.03.005 |
It is part of: | Toxicology Reports, 2017, vol. 4, p. 188-193 |
URI: | http://hdl.handle.net/2445/125261 |
Related resource: | https://doi.org/10.1016/j.toxrep.2017.03.005 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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