Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/125302
Title: | Model for probing membrane-cortex adhesion by micropipette aspirations and fluctuation spectroscopy |
Author: | Alert Zenón, Ricard Casademunt i Viader, Jaume Brugués, Jan Sens, Pierre |
Keywords: | Lligands Models biològics Viscositat Membranes cel·lulars Ligands Biological models Viscosity Cell membranes |
Issue Date: | 21-Apr-2015 |
Publisher: | Biophysical Society |
Abstract: | We propose a model for membrane-cortex adhesion which couples membrane deformations, hydrodynamics and kinetics of membrane-cortex ligands. In its simplest form, the model gives explicit predictions for the critical pressure for membrane detachment and for the value of adhesion energy. We show that these quantities exhibit a significant dependence on the active acto-myosin stresses. The model provides a simple framework to access quantitative information on cortical activity by means of micropipette experiments. We also extend the model to incorporate fluctuations and show that detailed information on the stability of membrane-cortex coupling can be obtained by a combination of micropipette aspiration and fluctuation spectroscopy measurements. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.bpj.2015.02.027 |
It is part of: | Biophysical Journal, 2015, vol. 108, num. 8, p. 1878-1886 |
URI: | http://hdl.handle.net/2445/125302 |
Related resource: | https://doi.org/10.1016/j.bpj.2015.02.027 |
ISSN: | 0006-3495 |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
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651917.pdf | 783.31 kB | Adobe PDF | View/Open |
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