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http://hdl.handle.net/2445/125313
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DC Field | Value | Language |
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dc.contributor.author | López, Abraham | - |
dc.contributor.author | Herranz-Trillo, F. | - |
dc.contributor.author | Kotev, Martin | - |
dc.contributor.author | Gairí Tahull, Margarida | - |
dc.contributor.author | Guallar, Victor | - |
dc.contributor.author | Bernadó Peretó, Pau | - |
dc.contributor.author | Millet Aguilar-Galindo, Òscar | - |
dc.contributor.author | Tarragó Clua, Maria Teresa | - |
dc.contributor.author | Giralt Lledó, Ernest | - |
dc.date.accessioned | 2018-10-15T16:40:37Z | - |
dc.date.available | 2018-10-15T16:40:37Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1439-4227 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125313 | - |
dc.description.abstract | Deciphering conformational dynamics is crucial for understanding the biological functions of proteins and for designing compounds targeting them. In particular, providing an accurate description of microsecond-millisecond motions opens the opportunity for regulating protein-protein interactions (PPIs) by modulating the dynamics of one interacting partner. Here we analyzed the conformational dynamics of prolyl oligopeptidase (POP) and the effects of active-site-directed inhibitors on the dynamics. We used an integrated structural biology approach based on NMR spectroscopy and SAXS experiments complemented by MD simulations. We found that POP is in a slow equilibrium in solution between open and closed conformations, and that inhibitors effectively abolished this equilibrium by stabilizing the enzyme in the closed conformation. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/cbic.201600102 | - |
dc.relation.ispartof | ChemBioChem, 2016, vol. 17, num. 10, p. 913-917 | - |
dc.relation.uri | https://doi.org/10.1002/cbic.201600102 | - |
dc.rights | (c) Wiley-VCH, 2016 | - |
dc.source | Articles publicats en revistes (Química Inorgànica i Orgànica) | - |
dc.subject.classification | Espectroscòpia de ressonància magnètica nuclear | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Nuclear magnetic resonance spectroscopy | - |
dc.subject.other | Proteins | - |
dc.title | Active site-directed inhibitors of prolyl oligopeptidase abolishes its conformational dynamics | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 662030 | - |
dc.date.updated | 2018-10-15T16:40:37Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26918396 | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
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662030.pdf | 2.29 MB | Adobe PDF | View/Open |
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