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DC Field | Value | Language |
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dc.contributor.author | Castellsagué, Xavier | - |
dc.contributor.author | Ault, Kevin A. | - |
dc.contributor.author | Bosch José, Francesc Xavier, 1947- | - |
dc.contributor.author | Brown, Darron | - |
dc.contributor.author | Cuzick, Jack | - |
dc.contributor.author | Ferris, Daron G. | - |
dc.contributor.author | Joura, Elmar A. | - |
dc.contributor.author | Garland, Suzanne M. | - |
dc.contributor.author | Giuliano, Anna R. | - |
dc.contributor.author | Hernández Avila, Mauricio | - |
dc.contributor.author | Huh, Warner | - |
dc.contributor.author | Iversen, Ole-Erik | - |
dc.contributor.author | Kjaer, Susanne Krüger | - |
dc.contributor.author | Luna, Joaquin | - |
dc.contributor.author | Monsonego, Joseph | - |
dc.contributor.author | Muñoz, Nubia | - |
dc.contributor.author | Myers, Evan | - |
dc.contributor.author | Paavonen, Jorma | - |
dc.contributor.author | Pitisuttihum, Punnee | - |
dc.contributor.author | Steben, Marc | - |
dc.contributor.author | Wheeler, Cosette M. | - |
dc.contributor.author | Perez, Gonzalo | - |
dc.contributor.author | Saah, Alfred | - |
dc.contributor.author | Luxembourg, Alain | - |
dc.contributor.author | Sings, Heather L. | - |
dc.contributor.author | Velicer, Christine | - |
dc.date.accessioned | 2018-10-16T12:58:40Z | - |
dc.date.available | 2018-10-16T12:58:40Z | - |
dc.date.issued | 2016-12-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/125353 | - |
dc.description.abstract | Background: We estimated the proportion of cervical intraepithelial neoplasia (CIN) cases attributed to 14 HPV types, including quadrivalent (qHPV) (6/11/16/18) and 9-valent (9vHPV) (6/11/16/18/31/33/45/52/58) vaccine types, by region Methods: Women ages 15-26 and 24-45 years from 5 regions were enrolled in qHPV vaccine clinical trials. Among 10,706 women (placebo arms), 1539 CIN1, 945 CIN2/3, and 24 adenocarcinoma in situ (AIS) cases were diagnosed by pathology panel consensus. Results: Predominant HPV types were 16/51/52/56 (anogenital infection), 16/39/51/52/56 (CIN1), and 16/31/52/58 (CIN2/3). In regions with largest sample sizes, minimal regional variation was observed in 9vHPV type prevalence in CIN1 (similar to 50%) and CIN2/3 (81-85%). Types 31/33/45/52/58 accounted for 25-30% of CIN1 in Latin America and Europe, but 14-18% in North America and Asia. Types 31/33/45/52/58 accounted for 33-38% of CIN2/3 in Latin America (younger women), Europe, and Asia, but 17-18% of CIN2/3 in Latin America (older women) and North America. Non-vaccine HPV types 35/39/51/56/59 had similar or higher prevalence than qHPV types in CIN1 and were attributed to 2-11% of CIN2/3. Conclusions: The 9vHPV vaccine could potentially prevent the majority of CIN1-3, irrespective of geographic region. Notwithstanding, non-vaccine types 35/39/51/56/59 may still be responsible for some CIN1, and to a lesser extent CIN2/3. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.pvr.2016.03.002 | - |
dc.relation.ispartof | Papillomavirus Research, 2016, vol. 2, p. 61-69 | - |
dc.relation.uri | https://doi.org/10.1016/j.pvr.2016.03.002 | - |
dc.rights | cc by-nc-nd (c) Castellsagué et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Papil·lomavirus | - |
dc.subject.classification | Càncer de coll uterí | - |
dc.subject.other | Papillomaviruses | - |
dc.subject.other | Cervix cancer | - |
dc.title | Human papillomavirus detection in cervical neoplasia attributed to 12 high-risk human papillomavirus genotypes by region | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:14:54Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29074187 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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CastellsagueX.pdf | 1.81 MB | Adobe PDF | View/Open |
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