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Title: Detecting the significant flux backbone of Escherichia coli metabolism
Author: Güell Riera, Oriol
Sagués i Mestre, Francesc
Serrano Moral, Ma. Ángeles (María Ángeles)
Keywords: Sistemes biològics
Escheríchia coli
Models biològics
Biological systems
Escherichia coli
Biological models
Issue Date: 2017
Publisher: FEBS Press
Abstract: The heterogeneity of computationally predicted reaction fluxes in metabolic networks within a single flux state can be exploited to detect their significant flux backbone. Here, we disclose the backbone of Escherichia coli, and compare it with the backbones of other bacteria. We find that, in general, the core of the backbones is mainly composed of reactions in energy metabolism corresponding to ancient pathways. In E. coli, the synthesis of nucleotides and the metabolism of lipids form smaller cores which rely critically on energy metabolism. Moreover, the consideration of different media leads to the identification of pathways sensitive to environmental changes. The metabolic backbone of an organism is thus useful to trace simultaneously both its evolution and adaptation fingerprints.
Note: Reproducció del document publicat a:
It is part of: FEBS Letters, 2017, vol. 591, num. 10, p. 1437-1451
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ISSN: 0014-5793
Appears in Collections:Articles publicats en revistes (Institut de Recerca en Sistemes Complexos (UBICS))
Articles publicats en revistes (Ciència dels Materials i Química Física)
Articles publicats en revistes (Física de la Matèria Condensada)

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