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Title: The importance of being dead: cell death mechanisms assessment in anti-sarcoma therapy
Author: Rello Varona, Santiago
Herrero Martín, David
Lagares Tena, Laura
López Alemany, Roser
Mulet Margalef, Núria
Huertas-Martínez, Juan
Garcia Monclús, Silvia
García del Muro Solans, Xavier
Muñoz Pinedo, Cristina
Martínez Tirado, Òscar
Keywords: Necrosi
Mort cel·lular
Cell death
Issue Date: 7-Apr-2015
Publisher: Frontiers Media
Abstract: Cell death can occur through different mechanisms, defined by their nature and physiological implications. Correct assessment of cell death is crucial for cancer therapy success. Sarcomas are a large and diverse group of neoplasias from mesenchymal origin. Among cell death types, apoptosis is by far the most studied in sarcomas. Albeit very promising in other fields, regulated necrosis and other cell death circumstances (as so-called "autophagic cell death" or "mitotic catastrophe") have not been yet properly addressed in sarcomas. Cell death is usually quantified in sarcomas by unspecific assays and in most cases the precise sequence of events remains poorly characterized. In this review, our main objective is to put into context the most recent sarcoma cell death findings in the more general landscape of different cell death modalities.
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It is part of: Frontiers in Oncology, 2015, num. 5, p. 82
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ISSN: 2234-943X
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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