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Title: Ruthenium complexes with phosphines containing the 1-pyrenyl substituent
Other Titles: Complexos de ruteni amb fosfines que contenen el grup 1-pirenil
Author: Ràfols Parellada, Laia
Director: Grabulosa, Arnald
Keywords: Ruteni
Compostos organometàl·lics
Medicaments antineoplàstics
Treballs de fi de grau
Organometallic compounds
Antineoplastic agents
Bachelor's thesis
Issue Date: Jun-2018
Abstract: The synthesis of eight Ru complexes with the general formula [RuI2(h6-arene)(PPyrR2)] (Pyr = 1-pyrenyl; arene = methyl benzoate or p-cymene), is described. These species were obtained from the parent dichlorocomplexes by treatment with an excess of sodium iodide in refluxing technical acetone for a period between 4 h and 11 days depending on the complex. Ru1-Ru4 stands for p-cymene complexes while Ru1’-Ru4’ are methyl benzoate complexes. Their structures were confirmed by IR, multinuclear NMR (31P, 1H, 13C), MS, EA and in three cases by single crystal X-ray diffraction. The antitumoral activity of these iodinated ruthenium complexes was studied against several cell lines and the results are promising compared to the chlorocomplexes. The synthesis of five new (1-pyrenyl)phosphines is also described. These ligands were designed taking into account the relation between the antitumoral activity and the bulkiness of the phosphines in dichlorocomplexes. The ligands have been obtained from the known dichlorophosphine L0. These phosphines were prepared adapting literature methods and have been characterised by the usual techniques.
Note: Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2018, Tutor: Arnald Grabulosa Rodríguez
Appears in Collections:Treballs Finals de Grau (TFG) - Química

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