Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/125929
Title: PDR-1/hParkin negatively regulates the phagocyosis of apoptotic cell corpses in Caenorhabditis elegans
Author: Cabello, J.
Sämann, J.
Gómez Orte, E.
Erazo, T.
Coppa, Andrea
Pujol Onofre, Aurora
Büssing, I.
Schulze, B.
Lizcano, J. M.
Baumeister, R.
Ferrer, Isidro (Ferrer Abizanda)
Dalfó Capella, Esther
Keywords: Mort cel·lular
Homeòstasi
Cell death
Homeostasis
Issue Date: 13-Mar-2014
Publisher: Nature Publishing Group
Abstract: Apoptotic cell death is an integral part of cell turnover in many tissues, and proper corpse clearance is vital to maintaining tissue homeostasis in all multicellular organisms. Even in tissues with high cellular turnover, apoptotic cells are rarely seen because of efficient clearance mechanisms in healthy individuals. In Caenorhabditis elegans, two parallel and partly redundant conserved pathways act in cell corpse engulfment. The pathway for cytoskeletal rearrangement requires the small GTPase CED-10 Rac1 acting for an efficient surround of the dead cell. The CED-10 Rac pathway is also required for the proper migration of the distal tip cells (DTCs) during the development of the C. elegans gonad. Parkin, the mammalian homolog of the C. elegans PDR-1, interacts with Rac1 in aged human brain and it is also implicated with actin dynamics and cytoskeletal rearrangements in Parkinsons's disease, suggesting that it might act on engulfment. Our genetic and biochemical studies indicate that PDR-1 inhibits apoptotic cell engulfment and DTC migration by ubiquitylating CED-10 for degradation.
Note: Reproducció del document publicat a: https://doi.org/10.1038/cddis.2014.57
It is part of: Cell Death and Disease, 2014, num. 5, p. e1120
Related resource: https://doi.org/10.1038/cddis.2014.57
URI: http://hdl.handle.net/2445/125929
ISSN: 2041-4889
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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