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http://hdl.handle.net/2445/126004
Title: | CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer |
Author: | Stefansson, Olafur A. Esteller, Manel |
Keywords: | Càncer Metàstasi Cromatina Cancer Metastasis Chromatin |
Issue Date: | 19-May-2014 |
Publisher: | BioMed Central |
Abstract: | In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues. This modification leads to the relocalization of BAF155-containing SWI/SNF complexes to regions containing genes involved in the Myc oncogenic pathway. The results presented are evidence that these interactions constitute a mechanism by which the BAF155 chromatin remodeling factor contributes to cancer. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/bcr3657 |
It is part of: | Breast Cancer Research, 2014, vol. 16, num. 3, p. 307 |
URI: | http://hdl.handle.net/2445/126004 |
Related resource: | https://doi.org/10.1186/bcr3657 |
ISSN: | 1465-542X |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Fisiològiques) |
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