Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126021
Title: | Global epigenomic reconfiguration during mammalian brain development |
Author: | Lister, Ryan Mukamel, Eran A. Nery, Joseph R. Urich, Mark Puddifoot, Clare A. Johnson, Nicholas D. Lucero, Jacinta Huang, Yun Dwork, Andrew J. Schultz, Matthew D. Yu, Miao Tonti Filippini, Julian Heyn, Holger Hu, Shijun Wu, Joseph C. Rao, Anjana Esteller, Manel He, Chuan Haghighi, Fatemeh G Sejnowski, Terrence J. Behrens, M. Margarita Ecker, Joseph R. |
Keywords: | ADN Aprenentatge Memòria DNA Learning Memory |
Issue Date: | 9-Aug-2013 |
Publisher: | American Association for the Advancement of Science |
Abstract: | DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain and that CG demethylation at these hmC-poised loci depends on Tet2 activity. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1126/science.1237905 |
It is part of: | Science, 2013, vol. 341, num. 6146 |
URI: | http://hdl.handle.net/2445/126021 |
Related resource: | https://doi.org/10.1126/science.1237905 |
ISSN: | 0036-8075 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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