Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126022
Title: Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia
Author: Berndt, Sonja I.
Skibola, Christine F.
Joseph, Vijai
Camp, Nicola J.
Nieters, Alexandra
Wang, Zhaoming
Cozen, Wendy
Monnereau, Alain
Wang, Sophia S.
Kelly, Rachel S.
Lan, Qing
Teras, Lauren R.
Chatterjee, Nilanjan
Chung, Charles C.
Yeager, Meredith
Brooks-Wilson, Angela R.
Hartge, Patricia
Purdue, Mark P.
Birmann, Brenda M.
Armstrong, Bruce K.
Cocco, Pierluigi
Zhang, Yawei
Severi, Gianluca
Zeleniuch-Jacquotte, Anne
Lawrence, Charles
Burdette, Laurie
Yuenger, Jeffrey
Hutchinson, Amy
Jacobs, Kevin B.
Call, Timothy G.
Shanafelt, Tait D.
Novak, Anne J.
Kay, Neil E.
Liebow, Mark
Wang, Alice H.
Smedby, Karin E.
Adami, Hans-Olov
Melbye, Mads
Glimelius, Bengt
Chang, Ellen T.
Glenn, Martha
Curtin, Karen
Cannon-Albright, Lisa A.
Jones, Brandt
Diver, W. Ryan
Link, Brian K.
Weiner, George J.
Conde, Lucia
Bracci, Paige M.
Riby, Jacques
Holly, Elizabeth A.
Smith, Martyn T.
Jackson, Rebecca D.
Tinker, Lesley F.
Benavente, Yolanda
Becker, Nikolaus
Boffetta, Paolo
Brennan, Paul
Foretova, Lenka
Maynadie, Marc
McKay, James
Staines, Anthony
Keywords: Leucèmia limfocítica crònica
Genòmica
Chronic lymphocytic leukemia
Genomics
Issue Date: 1-Jan-2013
Publisher: Nature Publishing Group
Abstract: Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL). To identify additional CLL susceptibility loci, we conducted the largest meta-analysis for CLL thus far, including four GWAS with a total of 3,100 individuals with CLL (cases) and 7,667 controls. In the meta-analysis, we identified ten independent associated SNPs in nine new loci at 10q23.31 (ACTA2 or FAS (ACTA2/FAS), P = 1.22 x 10(-14)), 18q21.33 (BCL2, P = 7.76 x 10(-11)), 11p15.5 (C11orf21, P = 2.15 x 10(-10)), 4q25 (LEF1, P = 4.24 x 10(-10)), 2q33.1 (CASP10 or CASP8 (CASP10/CASP8), P = 2.50 x 10(-9)), 9p21.3 (CDKN2B-AS1, P = 1.27 x 10(-8)), 18q21.32 (PMAIP1, P = 2.51 x 10(-8)), 15q15.1 (BMF, P = 2.71 x 10(-10)) and 2p22.2 (QPCT, P = 1.68 x 10(-8)), as well as an independent signal at an established locus (2q13, ACOXL, P = 2.08 x 10(-18)). We also found evidence for two additional promising loci below genome-wide significance at 8q22.3 (ODF1, P = 5.40 x 10(-8)) and 5p15.33 (TERT, P = 1.92 x 10(-7)). Although further studies are required, the proximity of several of these loci to genes involved in apoptosis suggests a plausible underlying biological mechanism.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/ng.2652
It is part of: Nature Genetics, 2013, vol. 8, num. 45, p. 868-876
Related resource: https://doi.org/10.1038/ng.2652
URI: http://hdl.handle.net/2445/126022
ISSN: 1061-4036
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
632357.pdf933.4 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.