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Title: Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort
Author: Duell, Eric J.
Luján Barroso, Leila
Llivina, Clàudia
Muñoz Miralles, Xavier
Jenab, Mazda
Boutron-Ruault, Marie-Christine
Clavel-Chapelon, Françoise
Racine, Antoine
Boeing, Heiner
Brian, Buijsse
Canzian, Federico
Johnson, Theron
Dalgård, Christine
Overvad, Kim
Tjønneland, Anne
Olsen, Anja
Sánchez, Soledad C.
Sánchez Cantalejo, Emilio
Huerta Castaño, José María
Ardanaz, Eva
Dorronsoro, Miren
Khaw, Kay-Tee
Travis, Ruth C.
Trichopoulou, Antonia
Trichopoulos, Dimitrios
Rafnsson, Snorri
Palli, Domenico
Sacerdote, Carlotta
Tumino, Rosario
Panico, Salvatore
Grioni, Sara
Bueno de Mesquita, H. Bas
Ros, Martine M.
Numans, Mattijs E.
Peeters, Petra H. M.
Johansen, Dorthe
Lindkvist, Björn
Johansson, Mattias
Sala Serra, Núria
González, Carlos Alberto
Johansson, Ingegerd
Skeie, Guri
Duarte Salles, Talita
Stenling, Roger
Riboli, Elio
Keywords: Vitamina C
Vitamin C
Issue Date: 5-Jun-2013
Publisher: BioMed Central
Abstract: Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. We also evaluated the association between these polymorphisms and baseline plasma vitamin C levels in a subset of participants. Four SNPs were predictors of plasma vitamin C levels (SLC23A1 rs11950646 and rs33972313; SLC23A2 rs6053005 and rs6133175) in multivariable linear regression models. One SNP (SLC23A2 rs6116569) was associated with GC risk, in particular non-cardia GC (OR = 1.63, 95 % CI = 1.11-2.39, based on 178 non-cardia cases), but this association was attenuated when plasma vitamin C was included in the logistic regression model. Haplotype analysis of SLC23A1 yielded no associations with GC. In SLC23A2, one haplotype was associated with both overall and non-cardia GC, another haplotype was associated with GC overall, and a third was associated with intestinal-type GC. Common variants in SLC23A1 and SLC23A2 may influence plasma vitamin C concentration independent of dietary intake, and variation in SLC23A2 may influence GC risk. Additional prospective studies in large populations and consortia are recommended. Investigation of variation in vitamin C transporter genes may shed light on the preventative properties of vitamin C in gastric carcinogenesis.
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It is part of: Genes & Nutrition, 2013, vol. 8, num. 6, p. 549-560
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ISSN: 1555-8932
Appears in Collections:Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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