Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126087
Full metadata record
DC FieldValueLanguage
dc.contributor.authorIzquierdo Serra, Mercè-
dc.contributor.authorTrauner, Dirk-
dc.contributor.authorLlobet Berenguer, Artur-
dc.contributor.authorGorostiza Langa, Pablo Ignacio-
dc.date.accessioned2018-11-14T10:39:22Z-
dc.date.available2018-11-14T10:39:22Z-
dc.date.issued2013-03-21-
dc.identifier.issn1662-5099-
dc.identifier.urihttp://hdl.handle.net/2445/126087-
dc.description.abstractA wide range of light-activated molecules (photoswitches and phototriggers) have been used to the study of computational properties of an isolated neuron by acting pre and postsynaptically. However, new tools are being pursued to elicit a presynaptic calcium influx that triggers the release of neurotransmitters, most of them based in calcium-permeable Channelrhodopsin-2 mutants. Here we describe a method to control exocytosis of synaptic vesicles through the use of a light-gated glutamate receptor (LiGluR), which has recently been demonstrated that supports secretion by means of calcium influx in chromaffin cells. Expression of LiGluR in hippocampal neurons enables reversible control of neurotransmission with light, and allows modulating the firing rate of the postsynaptic neuron with the wavelength of illumination. This method may be useful for the determination of the complex transfer function of individual synapses.-
dc.format.extent8 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherFrontiers Media-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3389/fnmol.2013.00003-
dc.relation.ispartofFrontiers In Molecular Neuroscience, 2013, vol. 6, num. 3-
dc.relation.urihttps://doi.org/10.3389/fnmol.2013.00003-
dc.rightscc-by (c) Izquierdo Serra, Mercè et al., 2013-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.subject.classificationCalci-
dc.subject.classificationNeurotransmissió-
dc.subject.classificationÒptica-
dc.subject.classificationSinapsi-
dc.subject.otherCalcium-
dc.subject.otherNeural transmission-
dc.subject.otherOptics-
dc.subject.otherSynapses-
dc.titleOptical modulation of neurotransmission using calcium photocurrents through the ion channel LiGluR-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec632202-
dc.date.updated2018-11-14T10:39:23Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
632202.pdf1.23 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons