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Title: Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study
Author: Romaguera, Dora
Ward, Heather A.
Wark, Petra A.
Vergnaud, Anne-Claire
Peeters, Petra H. M.
van Gils, Carla H.
Ferrari, Pietro
Fedirko, Veronika
Jenab, Mazda
Boutron-Ruault, Marie-Christine
Dossus, Laure
Dartois, Laureen
Plambeck Hansen, Camilla
Dahm, Christina Catherine
Buckland, Genevieve
Sánchez, María José
Dorronsoro, Miren
Navarro, Carmen
Barricarte, Aurelio
Key, Timothy J.
Trichopoulou, Antonia
Tsironis, Christos
Lagiou, Pagona
Masala, Giovanna
Pala, Valeria
Tumino, Rosario
Vineis, Paolo
Panico, Salvatore
Bueno de Mesquita, H. Bas
Siersema, Peter D.
Ohlsson, Bodil
Jirström, Karin
Wennberg, Maria
Nilsson, Lena M.
Weiderpass, Elisabete
Kühn, Tilman
Katzke, Verena Andrea
Khaw, Kay-Tee
Wareham, Nicholas J.
Tjønneland, Anne
Boeing, Heiner
Quirós, J. Ramón
Gunter, Marc
Riboli, Elio
Norat, Teresa
Keywords: Càncer colorectal
Condició física
Colorectal cancer
Physical fitness
Issue Date: 7-May-2015
Publisher: BioMed Central Ltd
Abstract: Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients. Methods: The association between the WCRF/AICR score (score range 0-6 in men and 0-7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality. Results: The HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25-2.75/3.25-3.75), third (3-3.75/4-4.75), and fourth (4-6/5-7) categories of the score were 0.87 (0.72-1.06), 0.74 (0.61-0.90), and 0.70 (0.56-0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0-2/0-3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models. Conclusions: Greater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients.
Note: Reproducció del document publicat a:
It is part of: BMC Medicine, 2015, vol. 13, num. 107
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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