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Title: | Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study |
Author: | Romaguera, Dora Ward, Heather A. Wark, Petra A. Vergnaud, Anne-Claire Peeters, Petra H. M. van Gils, Carla H. Ferrari, Pietro Fedirko, Veronika Jenab, Mazda Boutron-Ruault, Marie-Christine Dossus, Laure Dartois, Laureen Plambeck Hansen, Camilla Dahm, Christina C. Buckland, Genevieve Sánchez, María José Dorronsoro, Miren Navarro, Carmen Barricarte, Aurelio Key, Timothy J. Trichopoulou, Antonia Tsironis, Christos Lagiou, Pagona Masala, Giovanna Pala, Valeria Tumino, Rosario Vineis, Paolo Panico, Salvatore Bueno de Mesquita, H. Bas Siersema, Peter D. Ohlsson, Bodil Jirström, Karin Wennberg, Maria Nilsson, Lena Maria Weiderpass, Elisabete Kühn, Tilman Katzke, Verena Khaw, Kay-Tee Wareham, Nicholas J. Tjønneland, Anne Boeing, Heiner Quirós, J. Ramón Gunter, Marc J. Riboli, Elio Norat, Teresa |
Keywords: | Càncer colorectal Dieta Condició física Colorectal cancer Diet Physical fitness |
Issue Date: | 7-May-2015 |
Publisher: | BioMed Central Ltd |
Abstract: | Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients. Methods: The association between the WCRF/AICR score (score range 0-6 in men and 0-7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality. Results: The HRs (95% CIs) for CRC-specific mortality among participants in the second (score range in men/women: 2.25-2.75/3.25-3.75), third (3-3.75/4-4.75), and fourth (4-6/5-7) categories of the score were 0.87 (0.72-1.06), 0.74 (0.61-0.90), and 0.70 (0.56-0.89), respectively (P for trend <0.0001), compared to participants with the lowest concordance with the recommendations (category 1 of the score: 0-2/0-3). Similar HRs for overall mortality were observed (P for trend 0.004). Meeting the recommendations on body fatness and plant food consumption were associated with improved survival among CRC cases in mutually adjusted models. Conclusions: Greater concordance with the WCRF/AICR recommendations on diet, physical activity, and body fatness prior to CRC diagnosis is associated with improved survival among CRC patients. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s12916-015-0332-5 |
It is part of: | BMC Medicine, 2015, vol. 13, num. 107 |
URI: | http://hdl.handle.net/2445/126098 |
Related resource: | https://doi.org/10.1186/s12916-015-0332-5 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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