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Title: A Novel Role For Nanog As An Early Cancer Risk Marker In Patients With Laryngeal Precancerous Lesions
Author: Rodrigo, Juan P.
Villaronga, M. Ángeles
Menéndez, Sofia T.
Hermida Prado, Francisco
Quer, Miquel
Vilaseca González, Isabel
Allonca, Eva
Pedregal Mallo, Daniel
Astudillo, Aurora
Garcia-Pedrero, Juana M.
Keywords: Càncer de laringe
Cèl·lules mare embrionàries
Diferenciació cel·lular
Larynx cancer
Embryonic stem cells
Cell diferentiation
Issue Date: 11-Sep-2017
Publisher: Nature Publishing Group
Abstract: NANOG is a master regulator of embryonic stem cell pluripotency, found to be frequently aberrantly expressed in a variety of cancers, including laryngeal carcinomas. This study investigates for the first time the role of NANOG expression in early stages of laryngeal tumourigenesis and its potential utility as cancer risk marker. NANOG protein expression was evaluated by immunohistochemistry using two large independent cohorts of patients with laryngeal precancerous lesions, and correlated with clinicopathological parameters and laryngeal cancer risk. NANOG expression was detected by immunohistochemistry in 49 (60%) of 82 laryngeal dysplasias, whereas expression was negligible in patient-matched normal epithelia. Strong NANOG expression was found in 22 (27%) lesions and was established as cut-off point, showing the most robust association with laryngeal cancer risk (P = 0.003) superior to the histological classification (P = 0.320) the current gold standard in the clinical practice. Similar trends were obtained using a multicenter validation cohort of 86 patients with laryngeal dysplasia. Our findings uncover a novel role for NANOG expression in laryngeal tumourigenesis, and its unprecedented application as biomarker for cancer risk assessment.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2017, vol. 7, num. 11110
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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