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Title: Human Papillomavirus Antibodies And Future Risk Of Anogenital Cancer: A Nested Case-control Study In The European Prospective Investigation Into Cancer And Nutrition Study
Author: Kreimer, Aimée R.
Brennan, Paul
Lang Kuhs, Krystle A.
Waterboer, Tim
Clifford, Gary
Franceschi, Silvia
Michel, Angelika
Willhauck-Fleckenstein, Martina
Riboli, Elio
Castellsagué, Xavier
Hildesheim, Allan
Fortner, Renée T.
Kaaks, Rudolf
Palli, Domenico
Ljuslinder, Ingrid
Panico, Salvatore
Clavel-Chapelon, Françoise
Boutron-Ruault, Marie-Christine
Mesrine, Sylvie
Trichopoulou, Antonia
Lagiou, Pagona
Trichopoulos, Dimitrios
Peeters, Petra H. M.
Cross, Amanda J.
Bueno de Mesquita, H. Bas
Vineis, Paolo
Larrañaga, Nerea
Pala, Valeria
Sánchez, María José
Navarro, Carmen
Barricarte, Aurelio
Tumino, Rosario
Khaw, Kay-Tee
Wareham, Nicholas J.
Boeing, Heiner
Steffen, Annika
Travis, Ruth C.
Quirós, J. Ramón
Weiderpass, Elisabete
Pawlita, Michael
Johansson, Mattias
Keywords: Papil·lomavirus
Issue Date: 10-Mar-2015
Publisher: Amer Society of Clinical Oncology
Abstract: Purpose: Human papillomavirus (HPV) type 16 (HPV16) causes cancer at several anatomic sites. In the European Prospective Investigation Into Cancer and Nutrition study, HPV16 E6 seropositivity was present more than 10 years before oropharyngeal cancer diagnosis and was nearly absent in controls. The current study sought to evaluate the extent to which HPV16 E6 antibodies are present before diagnosis of anogenital cancers within the same cohort. Methods: Four hundred incident anogenital cancers (273 cervical, 24 anal, 67 vulvar, 12 vaginal, and 24 penile cancers) with prediagnostic blood samples (collected on average 3 and 8 years before diagnosis for cervix and noncervix cancers, respectively) and 718 matched controls were included. Plasma was analyzed for antibodies against HPV16 E6 and multiple other HPV proteins and genotypes and evaluated in relation to risk using unconditional logistic regression. Results: HPV16 E6 seropositivity was present in 29.2% of individuals (seven of 24 individuals) who later developed anal cancer compared with 0.6% of controls (four of 718 controls) who remained cancer free (odds ratio [OR], 75.9; 95% CI, 17.9 to 321). HPV16 E6 seropositivity was less common for cancers of the cervix (3.3%), vagina (8.3%), vulva (1.5%), and penis (8.3%). No associations were seen for non-type 16 HPV E6 antibodies, apart from anti-HPV58 E6 and anal cancer (OR, 6.8; 95% CI, 1.4 to 33.1). HPV16 E6 seropositivity tended to increase in blood samples drawn closer in time to cancer diagnosis. Conclusion: HPV16 E6 seropositivity is relatively common before diagnosis of anal cancer but rare for other HPV-related anogenital cancers.
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It is part of: Journal of Clinical Oncology, 2015, vol. 33, num. 8, p. 877-886
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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