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Title: A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Author: Vijai, Joseph
Wang, Zhaoming
Berndt, Sonja I.
Skibola, Christine F.
Slager, Susan L.
Sanjosé Llongueras, Silvia de
Melbye, Mads
Glimelius, Bengt
Bracci, Paige M.
Conde, Lucia
Birmann, Brenda M.
Giovannucci, Edward
Kraft, Peter
Virtamo, Jarmo
Smith, Alex
Kane, Eleanor
Roman, Eve
Chiu, Brian C. H.
Fraumeni, Joseph F.
Wu, Xifeng
Cerhan, James R.
Offit, Kenneth
Chanock, Stephen J.
Rothman, Nathaniel
Nieters, Alexandra
Wang, Sophia S.
Brooks-Wilson, Angela R.
Lan, Qing
Bakker, Paul I.W. de
Vermeulen, Roel C. H.
Portlock, Carol
Ansell, Stephen M.
Link, Brian K.
Riby, Jacques
North, Kari E.
Gu, Jian
Hjalgrim, Henrik
Cozen, Wendy
Becker, Nikolaus
Teras, Lauren R.
Spinelli, John J.
Turner, Jenny
Zhang, Yawei
Purdue, Mark P.
Giles, Graham G.
Kelly, Rachel S.
Zeleniuch-Jacquotte, Anne
Ennas, Maria Grazia
Monnereau, Alain
Bertrand, Kimberly A.
Albanes, Demetrius
Lightfoot, Tracy
Yeager, Meredith
Chung, Charles C.
Burdett, Laurie
Hutchinson, Amy
Lawrence, Charles
Montalvan, Rebecca
Liang, Liming
Huang, Jinyan
Ma, Baoshan
Villano, Danylo J.
Maria, Ann
Corines, Marina
Thomas, Tinu
Novak, Anne J.
Dogan, Ahmet
Liebow, Mark
Thompson, Carrie A.
Witzig, Thomas E.
Habermann, Thomas M.
Weiner, George J.
Smith, Martyn T.
Holly, Elizabeth A.
Jackson, Rebecca D.
Tinker, Lesley F.
Ye, Yuanqing
Adami, Hans-Olov
Smedby, Karin E.
Roos, Anneclaire J. De
Hartge, Patricia
Morton, Lindsay M.
Severson, Richard K.
Benavente, Yolanda
Boffetta, Paolo
Brennan, Paul
Foretova, Lenka
Maynadie, Marc
MCkay, James
Staines, Anthony
Diver, W. Ryan
Vajdic, Claire M.
Armstrong, Bruce K.
Kricker, Anne
Zheng, Tongzhang
Holford, Theodore R.
Severi, Gianluca
Vineis, Paolo
Ferri, Giovanni M.
Ricco, Rosalia
Miligi, Lucia
Clavel, Jacqueline
Keywords: Malaltia de Hodgkin
Cèl·lules B
Hodgkin's disease
B cells
Issue Date: 8-Jan-2015
Publisher: Nature Publishing Group
Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Note: Reproducció del document publicat a:
It is part of: Nature Communications, 2015, vol. 6
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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