Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126199
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | López Vicario, Cristina | - |
dc.contributor.author | Rius, Bibiana | - |
dc.contributor.author | Alcaraz-Quiles, José | - |
dc.contributor.author | González Périz, Ana | - |
dc.contributor.author | Martínez Puchol, Ana Isabel | - |
dc.contributor.author | Casulleras, Mireia | - |
dc.contributor.author | Duran Güell, Marta | - |
dc.contributor.author | Ibarzabal, Ainitze | - |
dc.contributor.author | Corcelles Codina, Ricard | - |
dc.contributor.author | Laguna Fernández, Andrés | - |
dc.contributor.author | Bäck, Magnus | - |
dc.contributor.author | Titos Rodríguez, Esther | - |
dc.contributor.author | Clària i Enrich, Joan | - |
dc.date.accessioned | 2018-11-16T17:30:12Z | - |
dc.date.available | 2018-11-16T17:30:12Z | - |
dc.date.issued | 2017-11-16 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126199 | - |
dc.description.abstract | Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1 beta, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-alpha 2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-017-15951-z | - |
dc.relation.ispartof | Scientific Reports, 2017, vol. 7, num. 15724 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-017-15951-z | - |
dc.rights | cc-by (c) López-Vicario, Cristina et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Teixit adipós | - |
dc.subject.classification | Obesitat mòrbida | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Comorbiditat | - |
dc.subject.classification | Polimorfisme genètic | - |
dc.subject.other | Adipose tissues | - |
dc.subject.other | Morbid obesity | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Comorbidity | - |
dc.subject.other | Genetic polymorphisms | - |
dc.title | Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 675730 | - |
dc.date.updated | 2018-11-16T17:30:12Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29146976 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
675730.pdf | 2.23 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License