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DC Field | Value | Language |
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dc.contributor.author | Podzamczer Palter, Daniel | - |
dc.contributor.author | Rozas, Nerea | - |
dc.contributor.author | Domingo, Pere (Domingo Pedrol) | - |
dc.contributor.author | Ocampo, Antonio | - |
dc.contributor.author | van den Eynde, Eva | - |
dc.contributor.author | Deig, Elisabeth | - |
dc.contributor.author | Vergara, Antonio | - |
dc.contributor.author | Knobel Freud, Hernando Javier | - |
dc.contributor.author | Pasquau, Juan | - |
dc.contributor.author | Antela, Antonio | - |
dc.contributor.author | Crespo, Manuel | - |
dc.contributor.author | Clotet, Bonaventura, 1953- | - |
dc.contributor.author | Muñoz, Jessica | - |
dc.contributor.author | Fernandez, Pedro | - |
dc.contributor.author | Geijo, Paloma | - |
dc.contributor.author | Rodríguez de Castro, Eduardo | - |
dc.contributor.author | Diz, Julio | - |
dc.contributor.author | Casado, Araceli | - |
dc.contributor.author | Torres, Covadonga | - |
dc.date.accessioned | 2018-11-21T14:01:39Z | - |
dc.date.available | 2018-11-21T14:01:39Z | - |
dc.date.issued | 2014-11-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126289 | - |
dc.description.abstract | Introduction: Tolerability and convenience are crucial aspects for the long-term success of combined antiretroviral therapy (cART). The aim of this study was to investigate the impact in routine clinical practice of switching to the single tablet regimen (STR) RPV/FTC/TDF in patients with intolerance to previous cART, in terms of patients’ well-being, assessed by several validated measures. Methods: Prospective, multicenter study. Adult HIV-infected patients with viral load under 1.000 copies/mL while receiving a stable ART for at least the last three months and switched to RPV/FTC/TDF due to intolerance of previous regimen, were included. Analyses were performed by ITT. Presence/magnitude of symptoms (ACTG-HIV Symptom Index), quality of life (EQ-5D, EUROQoL & MOS-HIV), adherence (SMAQ), preference of treatment and perceived ease of medication (ESTAR) through 48 weeks were performed. Results: Interim analysis of 125 patients with 16 weeks of follow up was performed. 100 (80%) were male, mean age 46 years. Mean CD4 at baseline was 629.59307.29 and 123 (98.4%) had viral load B50 copies/mL; 15% were HCV co-infected. Ninety two (73.6%) patients switched from a NNRTI (84.8% from EFV/FTC/TDF) and 33 (26.4%) from a PI/r. The most frequent reasons for switching were psychiatric disorders (51.2%), CNS adverse events (40.8%), gastrointestinal (19.2%) and metabolic disorders (19.2%). At the time of this analysis (week 16), four patients (3.2%) discontinued treatment: one due to adverse events, two virologic failures and one with no data. A total of 104 patients (83.2%) were virologically suppressed (B50 copies/mL). The average degree of discomfort in the ACTG-HIV Symptom Index significantly decreased from baseline (21915.55) to week 4 (10.89912.36) & week 16 (10.81912.62), pB0.001. In all the patients, quality of life tools showed a significant benefit in wellbeing of the patients (Table 1). Adherence to therapy significantly and progressively increased (SMAQ) from baseline (54.4%) to week 4 (68%), pB0.001 and to week 16 (72.0%), pB0.001. Conclusions: Switching to RPV/FTC/TDF from another ARV regimen due to toxicity, significantly improved the quality of life of HIV-infected patients, both in mental and physical components, and improved adherence to therapy while maintaining a good immune and virological response. | - |
dc.format.extent | 2 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.7448/IAS.17.4.19814 | - |
dc.relation.ispartof | Journal of the International AIDS Society, 2014, vol. 17, supl. 3 | - |
dc.relation.uri | https://doi.org/10.7448/IAS.17.4.19814 | - |
dc.rights | cc by (c) Podzamczer Palter et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.other | HIV infections | - |
dc.subject.other | Antiretroviral agents | - |
dc.title | ACTG-HIV symptoms changes in patients switched to RPV/FTC/TDF due to previous intolerance to CART. Interim analysis of the PROSTR study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:36:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25397558 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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PodzamczerD.pdf | 83.71 kB | Adobe PDF | View/Open |
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