Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126291
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Benavente, Yolanda | - |
dc.contributor.author | Sanjosé Llongueras, Silvia de | - |
dc.contributor.author | GWAS (Genome-wide Association Studies) | - |
dc.date.accessioned | 2018-11-21T14:10:25Z | - |
dc.date.available | 2018-11-21T14:10:25Z | - |
dc.date.issued | 2014-11-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126291 | - |
dc.description.abstract | Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10(-13) and 3.63 x 10(-11), respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL. | - |
dc.format.extent | 23 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/ng.3105 | - |
dc.relation.ispartof | Nature Genetics, 2014, vol. 46, num. 11, p. 1233-1238 | - |
dc.relation.uri | https://doi.org/10.1038/ng.3105 | - |
dc.rights | (c) Cerhan et al., 2014 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Limfomes | - |
dc.subject.classification | Cèl·lules B | - |
dc.subject.other | Lymphomas | - |
dc.subject.other | B cells | - |
dc.title | Genome-wide association study identifies multiple susceptibility loci for diffuse large B-cell lymphoma | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2018-07-24T12:36:43Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25261932 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
CerhanJR.pdf | 1.25 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.