Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126295
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aleksandrova, Krasimira | - |
dc.contributor.author | Pischon, Tobias | - |
dc.contributor.author | Jenab, Mazda | - |
dc.contributor.author | Bueno de Mesquita, H. Bas | - |
dc.contributor.author | Fedirko, Veronika | - |
dc.contributor.author | Norat, Teresa | - |
dc.contributor.author | Romaguera, Dora | - |
dc.contributor.author | Knüppel, Sven | - |
dc.contributor.author | Boutron-Ruault, Marie-Christine | - |
dc.contributor.author | Dossus, Laure | - |
dc.contributor.author | Dartois, Laureen | - |
dc.contributor.author | Kaaks, Rudolf | - |
dc.contributor.author | Li, Kuanrong | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Overvad, Kim | - |
dc.contributor.author | Quirós, J. Ramón | - |
dc.contributor.author | Buckland, Genevieve | - |
dc.contributor.author | Sánchez, María José | - |
dc.contributor.author | Dorronsoro, Miren | - |
dc.contributor.author | Chirlaque, María Dolores | - |
dc.contributor.author | Barricarte, Aurelio | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Wareham, Nicholas J. | - |
dc.contributor.author | Bradbury, Kathryn E. | - |
dc.contributor.author | Trichopoulou, Antonia | - |
dc.contributor.author | Lagiou, Pagona | - |
dc.contributor.author | Trichopoulos, Dimitrios | - |
dc.contributor.author | Palli, Domenico | - |
dc.contributor.author | Krogh, Vittorio | - |
dc.contributor.author | Tumino, Rosario | - |
dc.contributor.author | Naccarati, Alessio | - |
dc.contributor.author | Panico, Salvatore | - |
dc.contributor.author | Siersema, Peter D. | - |
dc.contributor.author | Peeters, Petra H. M. | - |
dc.contributor.author | Ljuslinder, Ingrid | - |
dc.contributor.author | Johansson, Ingegerd | - |
dc.contributor.author | Ericson, Ulrika | - |
dc.contributor.author | Ohlsson, Bodil | - |
dc.contributor.author | Weiderpass, Elisabete | - |
dc.contributor.author | Skeie, Guri | - |
dc.contributor.author | Benjaminsen Borch, Kristin | - |
dc.contributor.author | Rinaldi, Sabina | - |
dc.contributor.author | Romieu, Isabelle | - |
dc.contributor.author | Kong, Joyce | - |
dc.contributor.author | Gunter, Marc J. | - |
dc.contributor.author | Ward, Heather A. | - |
dc.contributor.author | Riboli, Elio | - |
dc.contributor.author | Boeing, Heiner | - |
dc.date.accessioned | 2018-11-21T14:19:43Z | - |
dc.date.available | 2018-11-21T14:19:43Z | - |
dc.date.issued | 2014-10-10 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126295 | - |
dc.description.abstract | Background: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors healthy weight, physical activity, non-smoking, limited alcohol consumption and a healthy diet, and to explore the association of this index with CRC incidence using data collected within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: In the EPIC cohort, a total of 347,237 men and women, 25- to 70-years old, provided dietary and lifestyle information at study baseline (1992 to 2000). Over a median follow-up time of 12 years, 3,759 incident CRC cases were identified. The association between a HLI and CRC risk was evaluated using Cox proportional hazards regression models and population attributable risks (PARs) have been calculated. Results: After accounting for study centre, age, sex and education, compared with 0 or 1 healthy lifestyle factors, the hazard ratio (HR) for CRC was 0.87 (95% confidence interval (CI): 0.44 to 0.77) for two factors, 0.79 (95% CI: 0.70 to 0.89) for three factors, 0.66 (95% CI: 0.58 to 0.75) for four factors and 0.63 (95% CI: 0.54 to 0.74) for five factors; P-trend <0.0001. The associations were present for both colon and rectal cancers, HRs, 0.61 (95% CI: 0.50 to 0.74; P for trend <0.0001) for colon cancer and 0.68 (95% CI: 0.53 to 0.88; P-trend <0.0001) for rectal cancer, respectively (P-difference by cancer sub-site = 0.10). Overall, 16% of the new CRC cases (22% in men and 11% in women) were attributable to not adhering to a combination of all five healthy lifestyle behaviours included in the index. Conclusions: Combined lifestyle factors are associated with a lower incidence of CRC in European populations characterized by western lifestyles. Prevention strategies considering complex targeting of multiple lifestyle factors may provide practical means for improved CRC prevention. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central Ltd | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12916-014-0168-4 | - |
dc.relation.ispartof | BMC Medicine, 2014, vol. 12, num. 168 | - |
dc.relation.uri | https://doi.org/10.1186/s12916-014-0168-4 | - |
dc.rights | cc by (c) Aleksandrova et al., 2014 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Estils de vida | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Lifestyles | - |
dc.title | Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T12:37:11Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/232997/EU//TICE | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25319089 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
AleksandrovaK.pdf | 492.64 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License