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Title: Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
Author: Wolpin, Brian M.
Rizzato, Cosmeri
Kraft, Peter
Kooperberg, Charles
Petersen, Gloria M.
Wang, Zhaoming
Arslan, Alan A.
Beane-Freeman, Laura
Bracci, Paige M.
Buring, Julie
Canzian, Federico
Landi, Maria T.
Landi, Stefano
Marchand, Loic Le
Mambrini, Andrea
Mannisto, Satu
Peters, Ulrike
Milne, Roger L.
Nakamura, Yusuke
Oberg, Ann L.
Owzar, Kouros
Rothman, Nathaniel
Patel, Alpa V.
Peeters, Petra H. M.
Pezzilli, Raffaele
Piepoli, Ada
Porta, Miquel
Real, Francisco X.
Riboli, Elio
Scarpa, Aldo
Shu, Xiao-Ou
Silverman, Debra T
Tjønneland, Anne
Soucek, Pavel
Sund, Malin
Talar-Wojnarowska, Renata
Taylor, Philip R.
Theodoropoulos, George E.
Yu, Herbert
Thornquist, Mark
Tobias, Geoffrey S.
Trichopoulos, Dimitrios
Vodicka, Pavel
Wactawski-Wende, Jean
Wentzensen, Nicolas
Wu, Chen
Yu, Kai
Zeleniuch-Jacquotte, Anne
Duell, Eric J.
Hoover, Robert
Hartge, Patricia
Fuchs, Charles
Chanock, Stephen J.
Stolzenberg-Solomon, Rachael Z.
Amundadottir, Laufey T.
Kolonel, Laurence N.
Gallinger, Steven
Giles, Graham G.
Goodman, Gary E.
Goodman, Phyllis J.
Jacobs, Eric J.
Kamineni, Aruna
Klein, Alison P.
Kulke, Matthew H.
Li, Donghui
Malats, Núria
Olson, Sara H.
Risch, Harvey A.
Sesso, Howard D.
Visvanathan, Kala
White, Emily
Zheng, Wei
Boutron-Ruault, Marie-Christine
Abnet, Christian C.
Albanes, Demetrius
Andreotti, Gabriella
Austin, Melissa A.
Barfield, Richard
Basso, Daniela
Berndt, Sonja I.
Brotzman, Michelle
Büchler, Markus W.
Bueno de Mesquita, H. Bas
Bugert, Peter
Burdette, Laurie
Campa, Daniele
Caporaso, Neil E.
Capurso, Gabriele
Chung, Charles
Giovannucci, Edward L.
Cotterchio, Michelle
Costello, Eithne
Elena, Joanne
Funel, Niccola
Gaziano, J. Michael
Giese, Nathalia A.
Goggins, Michael
Gorman, Megan J
Gross, Myron
Haiman, Christopher A.
Hassan, Manal
Helzlsouer, Kathy J.
Henderson, Brian E.
Holly, Elizabeth A.
Hu, Nan
Hunter, David J.
Kogevinas, Manolis
Innocenti, Federico
Jenab, Mazda
Kaaks, Rudolf
Key, Timothy J.
Khaw, Kay-Tee
Klein, Eric A.
Krogh, Vittorio
Kupcinskas, Juozas
Kurtz, Robert C.
LaCroix, Andrea
Keywords: Genòmica
Càncer de pàncrees
Pancreas cancer
Issue Date: 1-Sep-2014
Publisher: Nature Publishing Group
Abstract: We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 x 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 x 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 x 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 x 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 x 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 x 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
Note: Versió postprint del document publicat a:
It is part of: Nature Genetics, 2014, vol. 46, num. 9, p. 994-1000
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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