Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126372
Title: In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior
Author: Carvajal Cuenca, Alejandra
Sua, Luz F.
Silva, Nhora M.
Pittaluga, Stefania
Royo, Cristina
Song, Joo Y.
Sargent, Rachel L.
Espinet, Blanca
Climent, Fina
Jacobs, Samuel A.
Delabie, Jan
Naresh, Kikkeri N.
Bagg, Adam
Brousset, Pierre
Warnke, Roger A.
Serrano, Sergi
Harris, Nancy Lee
Swerdlow, Steven H.
Jaffe, Elaine S.
Campo Güerri, Elias
Keywords: Cèl·lules canceroses
Limfomes
Genètica
Cancer cells
Lymphomas
Genetics
Issue Date: Feb-2012
Publisher: Ferrata Storti Foundation
Abstract: Background Cyclin D1-positive B cells are occasionally found in the mantle zones of reactive lymphoid follicles, a condition that has been called 'in situ mantle cell lymphoma'. The clinical significance of this lesion remains uncertain. Design and Methods The clinical and pathological characteristics, including SOX11 expression, of 23 cases initially diagnosed as in situ mantle cell lymphoma were studied. Results Seventeen of the 23 cases fulfilled the criteria for in situ mantle cell lymphoma. In most cases, the lesions were incidental findings in reactive lymph nodes. The t(11; 14) was detected in all eight cases examined. SOX11 was positive in seven of 16 cases (44%). Five cases were associated with other small B-cell lymphomas. In two cases, both SOX11-positive, the in situ mantle cell lymphoma lesions were discovered after the diagnosis of overt lymphoma; one 4 years earlier, and one 3 years later. Twelve of the remaining 15 patients had a follow-up of at least 1 year (median 2 years; range, 1-19.5), of whom 11 showed no evidence of progression, including seven who were not treated. Only one of 12 patients with an in situ mantle cell lymphoma lesion and no diagnosis of mantle cell lymphoma at the time developed an overt lymphoma, 4 years later; this case was also SOX11-positive. The six remaining cases were diagnosed as mantle cell lymphoma with a mantle zone pattern. Five were SOX11-positive and four of them were associated with lymphoma without a mantle zone pattern. Conclusions In situ mantle cell lymphoma lesions are usually an incidental finding with a very indolent behavior. These cases must be distinguished from mantle cell lymphoma with a mantle zone pattern and overt mantle cell lymphoma because they may not require therapeutic intervention.
Note: Reproducció del document publicat a: https://doi.org/10.3324/haematol.2011.052621
It is part of: Haematologica, 2012, vol. 97, num. 2, p. 270-278
Related resource: https://doi.org/10.3324/haematol.2011.052621
URI: http://hdl.handle.net/2445/126372
ISSN: 0390-6078
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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