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Title: Diabetes and risk of pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium
Author: Elena, Joanne W.
Steplowski, Emily
Yu, Kai
Hartge, Patricia
Tobias, Geoffrey S.
Brotzman, Michelle J.
Chanock, Stephen J.
Stolzenberg-Solomon, Rachael Z.
Arslan, Alan A.
Bueno de Mesquita, H. Bas
Helzlsouer, Kathy
Jacobs, Eric J.
LaCroix, Andrea
Petersen, Gloria
Zheng, Wei
Albanes, Demetrius
Allen, Naomi E.
Amundadottir, Laufey
Bao, Ying
Boeing, Heiner
Boutron-Ruault, Marie-Christine
Buring, Julie E.
Gaziano, J. Michael
Giovannucci, Edward L.
Duell, Eric J.
Hallmans, Göran
Howard, Barbara V.
Hunter, David J.
Hutchinson, Amy
Jacobs, Kevin B.
Kooperberg, Charles
Kraft, Peter
Mendelsohn, Julie B.
Michaud, Dominique S.
Palli, Domenico
Phillips, Lawrence S.
Overvad, Kim
Patel, Alpa V.
Sansbury, Leah
Shu, Xiao-Ou
Simon, Michael S.
Slimani, Nadia
Trichopoulos, Dimitrios
Visvanathan, Kala
Virtamo, Jarmo
Wolpin, Brian M.
Zeleniuch-Jacquotte, Anne
Fuchs, Charles S.
Hoover, Robert N.
Gross, Myron
Keywords: Diabetis
Càncer de pàncrees
Pancreas cancer
Issue Date: Jan-2013
Publisher: Springer
Abstract: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (< 2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.
Note: Versió postprint del document publicat a:
It is part of: Cancer Causes & Control, 2013, vol. 24, num. 1, p. 13-25
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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