Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126477
Title: | Smoking, Variation In N-acetyltransferase 1 (nat1) And 2 (nat2), And Risk Of Non-hodgkin Lymphoma: A Pooled Analysis Within The Interlymph Consortium |
Author: | Gibson, Todd M. Smedby, Karin E. Skibola, Christine F. Hein, David W. Slager, Susan L. Sanjosé Llongueras, Silvia de Vajdic, Claire M. Zhang, Yawei Chiu, Brian C. H. Wang, Sophia S. Hjalgrim, Henrik Nieters, Alexandra Bracci, Paige M. Kricker, Anne Zheng, Tongzhang Kolar, Carol Cerhan, James R. Darabi, Hatef Becker, Nikolaus Conde, Lucía Holford, Theodore R. Weisenburger, Dennis D. Roos, Anneclaire J. De Butterbach, Katja Riby, Jacques Cozen, Wendy Benavente, Yolanda Palmers, Casey Holly, Elizabeth A. Sampson, Joshua N. Rothman, Nathaniel Armstrong, Bruce K. Morton, Lindsay M. |
Keywords: | Malaltia de Hodgkin Hàbit de fumar Hodgkin's disease Smoking |
Issue Date: | Jan-2013 |
Publisher: | Springer |
Abstract: | Studies of smoking and risk of non-Hodgkin lymphoma (NHL) have yielded inconsistent results, possibly due to subtype heterogeneity and/or genetic variation impacting the metabolism of tobacco-derived carcinogens, including substrates of the N-acetyltransferase enzymes NAT1 and NAT2. We conducted a pooled analysis of 5,026 NHL cases and 4,630 controls from seven case-control studies in the international lymphoma epidemiology consortium to examine associations between smoking, variation in the N-acetyltransferase genes NAT1 and NAT2, and risk of NHL subtypes. Smoking data were harmonized across studies, and genetic variants in NAT1 and NAT2 were used to infer acetylation phenotype of the NAT1 and NAT2 enzymes, respectively. Pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for risk of NHL and subtypes were calculated using joint fixed effects unconditional logistic regression models. Current smoking was associated with a significant 30 % increased risk of follicular lymphoma (n = 1,176) but not NHL overall or other NHL subtypes. The association was similar among NAT2 slow (OR 1.36; 95 % CI 1.07-1.75) and intermediate/rapid (OR 1.27; 95 % CI 0.95-1.69) acetylators (p (interaction) = 0.82) and also did not differ by NAT1*10 allelotype. Neither NAT2 phenotype nor NAT1*10 allelotype was associated with risk of NHL overall or NHL subtypes. The current findings provide further evidence for a modest association between current smoking and follicular lymphoma risk and suggest that this association may not be influenced by variation in the N-acetyltransferase enzymes. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/s10552-012-0098-4 |
It is part of: | Cancer Causes & Control, 2013, vol. 24, num. 1, p. 125-134 |
URI: | http://hdl.handle.net/2445/126477 |
Related resource: | https://doi.org/10.1007/s10552-012-0098-4 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
GibsonTM.pdf | 310.55 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.