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Title: Increased risk of lung cancer in individuals with a family history of the disease: A pooled analysis from the International Lung Cancer Consortium
Author: Cote, Michele L.
Liu, Mei
Bonassi, Stefano
Neri, Monica
Schwartz, Ann G.
Christiani, David C.
Spitz, Margaret R.
Muscat, Joshua E.
Rennert, Gad
Aben, Katja K.
Andrew, Angeline S.
Bencko, Vladimir
Bickeboller, Heike
Boffetta, Paolo
Brennan, Paul
Brenner, Hermann
Duell, Eric J.
Fabianova, Eleonora
Field, John K.
Foretova, Lenka
Friis, Søren
Harris, Curtis C.
Holcátová, Ivana
Hong, Yun-Chul
Isla, Dolores
Janout, Vladimir
Kiemeney, Lambertus A. L. M.
Kiyohara, Chikako
Lan, Qing
Lazarus, Philip
Lissowska, Jolanta
Marchand, Loic Le
Mates, Dana
Matsuo, Keitaro
Mayordomo, Jose Ignacio
McLaughlin, John R.
Morgenstern, Hal
Müeller, Heiko
Orlow, Irene
Park, Bernard J.
Pinchev, Mila
Raji, Olaide Y.
Rennert, Hedy S.
Rudnai, Peter
Seow, Adeline
Stucker, Isabelle
Szeszenia-Dabrowska, Neonila
Teare, M. Dawn
Tjønneland, Anne
Ugolini, Donatella
van der Heijden, Henricus F. M.
Wichmann, H.-Erich
Wiencke, John K.
Woll, Penella
Yang, Ping
Zaridze, David
Zhang, Zuo-Feng
Etzel, Carol J.
Hung, Rayjean J.
Keywords: Càncer de pulmó
Lung cancer
Issue Date: Sep-2012
Publisher: Elsevier
Abstract: Background and methods: Familial aggregation of lung cancer exists after accounting for cigarette smoking. However, the extent to which family history affects risk by smoking status, histology, relative type and ethnicity is not well described. This pooled analysis included 24 case-control studies in the International Lung Cancer Consortium. Each study collected age of onset/interview, gender, race/ethnicity, cigarette smoking, histology and first-degree family history of lung cancer. Data from 24,380 lung cancer cases and 23,305 healthy controls were analysed. Unconditional logistic regression models and generalised estimating equations were used to estimate odds ratios and 95% confidence intervals. Results: Individuals with a first-degree relative with lung cancer had a 1.51-fold increase in the risk of lung cancer, after adjustment for smoking and other potential confounders (95% CI: 1.39, 1.63). The association was strongest for those with a family history in a sibling, after adjustment (odds ratios (OR) = 1.82, 95% CI: 1.62, 2.05). No modifying effect by histologic type was found. Never smokers showed a lower association with positive familial history of lung cancer (OR = 1.25, 95% CI: 1.03, 1.52), slightly stronger for those with an affected sibling (OR = 1.44, 95% CI: 1.07, 1.93), after adjustment. Conclusions: The occurrence of lung cancer among never smokers and similar magnitudes of the effect of family history on lung cancer risk across histological types suggests familial aggregation of lung cancer is independent of those risks associated with cigarette smoking. While the role of genetic variation in the aetiology of lung cancer remains to be fully characterised, family history assessment is immediately available and those with a positive history represent a higher risk group.
Note: Versió postprint del document publicat a:
It is part of: European Journal of Cancer, 2012, vol. 48, num. 13, p. 1957-1968
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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