Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126522
Title: Detectable clonal mosaicism and its relationship to aging and cancer
Author: Jacobs, Kevin B.
Yeager, Meredith
Zhou, Weiyin
Wacholder, Sholom
Wang, Zhaoming
Rodriguez-Santiago, Benjamin
Hutchinson, Amy
Deng, Xiang
Liu, Chenwei
Horner, Marie-Josephe
Cullen, Michael
Sampson, Joshua
Sesso, Howard D.
Ding, Ti
McWilliams, Robert R.
Riboli, Elio
Qiao, You-Lin
Chatterjee, Nilanjan
Zanetti, Krista A.
Gonzalez, Juan R.
Savage, Sharon A.
Silverman, Debra T.
Amos, Christopher I.
Tang, Ze-Zhong
Sierrasesúmaga, Luis
Consonni, Dario
Albanes, Demetrius
Olson, Sara H.
Chow, Wong-Ho
Krogh, Vittorio
Beane Freeman, Laura
Kratz, Christian P.
Holly, Elizabeth A.
Blot, William J.
Hallmans, Göran
Peters, Ulrike
Duell, Eric J.
Yu, Herbert
Hoover, Robert N.
Caporaso, Neil E .
Bertazzi, Pier Alberto
Chanock, Stephen J.
Erickson, Ralph L.
Elena, Joanne W.
Visvanathan, Kala
Tobias, Geoffrey S.
Rothman, Nathaniel
Hassan, Manal
Chang, Kenneth
Cotterchio, Michelle
Johnson, Alison
Moore, Lee E.
Rajaraman, Preetha
Purdue, Mark
Klein, Alison P.
Wheeler, William
Wentzensen, Nicolas
Arslan, Alan A.
Petersen, Gloria
Chatterjee, Nilanjan
Canzian, Federico
Goggins, Michael
Landi, Maria Teresa
Kurtz, Robert C.
Graubard, Barry I.
Kovaks, Joseph
Marenne, Gaelle
Dean, Michael C.
Giovannucci, Edward L.
Wunder, Jay S.
Andrulis, Irene L.
Butler, Mary A.
Jenab, Mazda
Bueno de Mesquita, H. Bas
Marchand, Loic Le
Carreon, Tania
Goldin, Lynn
Ruder, Avima M.
Peplonska, Beata
Burdett, Laurie
Sampson, Joshua
Gorlick, Richard G.
Fuchs, Charles S.
Chung, Charles C.
Barkauskas, Donald A.
Taylor, Philip R.
Haiman, Christopher A.
Hunter, David J.
Gapstur, Susan M.
Giles, Graham G.
White, Emily
Mendelsohn, Julie B.
Zheng, Wei
Lissowska, Jolanta
Amundadottir, Laufey
Andersson, Ulrika
Davis, Faith G.
Boutron-Ruault, Marie-Christine
Lacroix, Andrea
Rabe, Kari G.
Gallinger, Steven
Trichopoulos, Dimitrios
Brinton, Louise A.
Gross, Myron D.
Tjønneland, Anne
Kovaks, Joseph
Virtamo, Jarmo
Dean, Michael C.
Freedman, Neal D.
Hankinson, Susan E.
Bracci, Paige M.
McKean-Cowdin, Roberta
Weinstein, Stephanie J.
Mandelson, Margaret T.
Gao, Yu-Tang
Kolonel, Laurence N.
Harris, Curtis C.
Teras, Lauren T.
Fraumeni Jr., Joseph F.
Greene, Mark H.
Mirabello, Lisa
Schwartz, Kendra L.
Risch, Harvey A.
Abnet, Christian C.
Prokunina-Olsson, Ludmila
Garcia Closas, Montserrat
Michaud, Dominique S.
Stevens, Victoria L.
Signorello, Lisa B.
Tucker, Margaret
Aldrich, Melinda C.
Stram, Daniel
Kraft, Peter
Pérez Jurado, Luis A.
Berg, Christine D.
Hoffman Bolton, Judith A.
Koh, Woon-Puay
Buring, Julie E.
Ziegler, Regina G.
Bock, Cathryn H.
Feychting, Maria
Goldstein, Alisa M.
Hartge, Patricia
Johansen, Christoffer
Hu, Nan
Patiño García, Ana
Rotunno, Melissa
Gillanders, Elizabeth M.
Rybicki, Benjamin A.
Spitz, Margaret R.
Gaziano, J. Michael
Epstein, Caroline G.
Khaw, Kay-Tee
Inskip, Peter D.
Melin, Beatrice S.
Severi, Gianluca
McGlynn, Katherine A.
Wolpin, Brian M.
Henriksson, Roger
Stolzenberg-Solomon, Rachael Z.
Gaudet, Mia M.
Wu, Xifeng
Berndt, Sonja I.
Yu, Kai
Hsing, Ann W.
Landgren, Annelie
Wolk, Alicja
Xiang, Yong-Bing
Ahlbom, Anders
Cook, Michael B.
Black, Amanda
Baris, Dalsu
Yuan, Jian-Min
Li, Donghui
Malats, Nuria
Jiao, Li
Kogevinas, Manolis
Kooperberg, Charles
Villa, Olaya
Real, Francisco X.
Schumacher, Fredrick
Liao, Linda
Schwartz, Ann G.
McNeill, Lorna H.
Schwenn, Molly
Figueroa, Jonine D.
Henderson, Brian E.
Shu, Xiao-Ou
Zeleniuch-Jacquotte, Anne
Wiencke, John K.
Fan, Jin-Hu
Thomas, Gilles
Wrensch, Margaret
Keywords: Càncer
Envelliment
Cancer
Aging
Issue Date: 6-May-2012
Publisher: Nature Publishing Group
Abstract: In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of > 2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 x 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 x 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases.
Note: Versió postprint del document publicat a: https://doi.org/10.1038/ng.2270
It is part of: Nature Genetics, 2012, vol. 44, num. 6, p. 651-U68
URI: http://hdl.handle.net/2445/126522
Related resource: https://doi.org/10.1038/ng.2270
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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