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Title: Dopamine D(4) receptor, but not the ADHD-associated D(4.7) variant, forms functional heteromers with the dopamine D(2S) receptor in the brain
Author: González, Sergio
Rangel-Barajas, C.
Peper, Marcela
Lorenzo, Ramiro
Moreno Guillén, Estefanía
Ciruela Alférez, Francisco
Borycz, Janusz
Ortiz, Jordi
Lluís i Biset, Carme
Franco Fernández, Rafael
McCormick, Peter J.
Volkow, Nora D.
Rubinstein, Marcelo
Floran, Benjamin
Ferré, Sergi
Keywords: Dopamina
Receptors cel·lulars
Cell receptors
Issue Date: 16-Aug-2011
Publisher: Nature Publishing Group
Abstract: Polymorphic variants of the dopamine D4 receptor have been consistently associated with attention-deficit hyperactivity disorder (ADHD). However, the functional significance of the risk polymorphism (variable number of tandem repeats in exon 3) is still unclear. Here, we show that whereas the most frequent 4-repeat (D4.4) and the 2-repeat (D4.2) variants form functional heteromers with the short isoform of the dopamine D2 receptor (D2S), the 7-repeat risk allele (D4.7) does not. D2 receptor activation in the D2S-D4 receptor heteromer potentiates D4 receptor-mediated MAPK signaling in transfected cells and in the striatum, which did not occur in cells expressing D4.7 or in the striatum of knockin mutant mice carrying the 7 repeats of the human D4.7 in the third intracellular loop of the D4 receptor. In the striatum, D4 receptors are localized in corticostriatal glutamatergic terminals, where they selectively modulate glutamatergic neurotransmission by interacting with D2S receptors. This interaction shows the same qualitative characteristics than the D2S-D4 receptor heteromer-mediated mitogen-activated protein kinase (MAPK) signaling and D2S receptor activation potentiates D4 receptor-mediated inhibition of striatal glutamate release. It is therefore postulated that dysfunctional D2S-D4.7 heteromers may impair presynaptic dopaminergic control of corticostriatal glutamatergic neurotransmission and explain functional deficits associated with ADHD.
Note: Versió postprint del document publicat a:
It is part of: Molecular Psychiatry, 2011, vol. 17, p. 650-662
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ISSN: 1359-4184
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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