Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126627
Title: Anthropometric characteristics and non-Hodgkin’s lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Author: Britton, Julie A.
Khan, Aneire E.
Rohrmann, Sabine
Becker, Nikolaus
Linseisen, Jakob
Nieters, Alexandra
Kaaks, Rudolf
Tjønneland, Anne
Halkjær, Jytte
Severinsen, Marianne Tang
Overvad, Kim
Pischon, Tobias
Boeing, Heiner
Trichopoulou, Antonia
Kalapothaki, Victoria
Trichopoulos, Dimitrios
Mattiello, Amalia
Tagliabue, Giovanna
Sacerdote, Carlotta
Peeters, Petra H. M.
Bueno de Mesquita, H. Bas
Ardanaz, Eva
Navarro, Carmen
Jakszyn, Paula
Altzibar, Jone M.
Hallmans, Göran
Malmer, Beatrice
Berglund, Göran
Manjer, Jonas
Allen, Naomi
Key, Timothy
Bingham, Sheila
Besson, Hervé
Ferrari, Pietro
Jenab, Mazda
Boffetta, Paolo
Vineis, Paolo
Riboli, Elio
Keywords: Malaltia de Hodgkin
Antropometria
Hodgkin's disease
Anthropometry
Issue Date: Nov-2008
Publisher: Ferrata Storti Foundation
Abstract: Background: The incidences of non-Hodgkin's lymphoma and multiple myeloma are increasing steadily. It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma. Design and Methods: In the context of the European Prospective Investigation into Cancer and Nutrition (EPIC), anthropometric characteristics were assessed in 371,983 cancer-free individuals at baseline. During the 8.5 years of follow-up, 1,219 histologically confirmed incident cases of non-Hodgkin's lymphoma and multiple myeloma occurred in 609 men and 610 women. Gender-specific proportional hazards models were used to estimate relative risks and 95% confidence intervals (95% CI) of development of non-Hodgkin's lymphoma and multiple myeloma in relation to the anthropometric characteristics. Results: Height was associated with overall non-Hodgkin's lymphoma and multiple myeloma in women (RR 1.50,95% CI 1.14-1.98) for highest versus lowest quartile; p-trend <0.01) but not in men. Neither obesity (weight and body mass index) nor abdominal fat (waist-to-hip ratio, waist or hip circumference) measures were positively associated with overall non-Hodgkin's lymphoma and multiple myeloma. Relative risks for highest versus lowest body mass index quartile were 1.09 (95% CI 0.85-1.38) and 0.92 (95% CI 0.71-1.19) for men and women, respectively. Women in the upper body mass index quartile were at greater risk of diffuse large B-cell lymphoma (RR 2.18, 95% CI 1.05-4.53) and taller women had an elevated risk of follicular lymphoma (RR 1.25, 95% CI 0.59-2.62). Among men, height and body mass index were non-significantly, positively related to follicular lymphoma. Multiple myeloma risk alone was elevated for taller women (RR 2.34, 95% CI 1.29-4.21) and heavier men (RR 1.77, 95% CI 1.02-3.05). Conclusions: The EPIC analyses support an association between height and overall non-Hodgkin's lymphoma and multiple myeloma among women and suggest heterogeneous subtype associations. This is one of the first prospective studies focusing on central adiposity and non-Hodgkin's lymphoma subtypes.
Note: Reproducció del document publicat a: https://doi.org/10.3324/haematol.13078
It is part of: Haematologica, 2008, vol. 93, num. 11, p. 1666-1677
URI: http://hdl.handle.net/2445/126627
Related resource: https://doi.org/10.3324/haematol.13078
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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