Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/126753
Title: Quality of life in Cushing's disease: a long term issue?
Author: Webb, S. M. (Susan M.), 1952-
Santos Vives, Alicia
Resmini, Eugenia
Martínez Momblán, Ma. Antonia
Martel, Luciana
Valassi, Elena
Keywords: Qualitat de vida
Comorbiditat
Ansietat
Síndrome de Cushing
Quality of life
Comorbidity
Anxiety
Cushing's syndrome
Issue Date: Jun-2018
Publisher: Elsevier Masson SAS
Abstract: The purpose of this review is to describe how quality of life (QoL) is impaired in patients with hypercortisolism due to Cushing's syndrome of any aetiology, including pituitary-dependent Cushing's disease. It is worse in active disease, but improvement after successful therapy is often incomplete, due to persistent physical and psychological co-morbidities, even years after endocrine "cure". Physical symptoms like extreme fatigability, central obesity with limb atrophy, hypertension, fractures, and different skin abnormalities severely impair the affected patients' everyday life. Psychological and cognitive problems like bad memory, difficulties to concentrate and emotional distress, often associated with anxiety and depression, make it difficult for many patients to overcome the aftermath of treated Cushing's syndrome. Recent studies have shown diffuse structural abnormalities in the central nervous system during active hyper-cortisolism, thought to be related to the wide distribution of glucocorticoid receptors throughout the brain. Even though they improve after treatment, normalization is often not complete. Shortening the exposure to active Cushing's syndrome by reducing the often long delay to diagnosis and promptly receiving effective treatment is highly desirable, together with preparing the patient for the difficult periods, especially after surgery. In this way they are prepared for the impairments they perceive in every day life, and live with the hope of later improvement, which can be therapeutic in many instances.
Note: Versió postprint del document publicat a: https://doi.org/10.1016/j.ando.2018.03.007
It is part of: Annales d'Endocrinologie, 2018, vol. 79, num. 3, p. 132-137
Related resource: https://doi.org/10.1016/j.ando.2018.03.007
URI: http://hdl.handle.net/2445/126753
ISSN: 0003-4266
Appears in Collections:Articles publicats en revistes (Infermeria Fonamental i Medicoquirúrgica)

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