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Title: Intrauterine growth restriction and later cardiovascular function
Author: Crispi Brillas, Fàtima
Crovetto, Francesca
Gratacós Solsona, Eduard
Keywords: Monitoratge fetal
Malalties cardiovasculars
Retard del creixement intrauterí
Fetal monitoring
Cardiovascular diseases
Fetal growth retardation
Issue Date: Nov-2018
Publisher: Elsevier B.V.
Abstract: Intrauterine growth restriction is one of the most common obstetric conditions, affecting 7-10% of fetuses. Affected fetuses are actually exposed in utero to an adverse environment during the highly critical time of development and may face life-long health consequences such as increased cardiovascular risk in adulthood. Already in utero, fetuses affected by growth restriction show remodeled hearts with signs of systolic and diastolic dysfunction. Cardiovascular remodeling persist into postnatal life, from the neonatal period to adolescence, suggesting a primary fetal cardiac programming that might explain the increased cardiovascular risk later in life. In this review we summarize the current evidence on fetal cardiovascular programming in fetuses affected by growth restriction, its consequences later and possible strategies from which they could benefit to reduce their cardiovascular risk.
Note: Versió postprint del document publicat a:
It is part of: Early Human Development, 2018, vol. 126
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ISSN: 0378-3782
Appears in Collections:Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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