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DC Field | Value | Language |
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dc.contributor.author | Villà, Salvador | - |
dc.contributor.author | Weber, Damien C. | - |
dc.contributor.author | Moretones, Cristina | - |
dc.contributor.author | Manes, Anabel | - |
dc.contributor.author | Combescure, Christophe | - |
dc.contributor.author | Jové, Josep | - |
dc.contributor.author | Puyalto, Paloma | - |
dc.contributor.author | Cuadras, Patricia | - |
dc.contributor.author | Bruna, Jordi | - |
dc.contributor.author | Verger, Eugènia | - |
dc.contributor.author | Balaña, Carmen | - |
dc.contributor.author | Graus Ribas, Francesc | - |
dc.date.accessioned | 2018-12-07T10:50:36Z | - |
dc.date.available | 2018-12-07T10:50:36Z | - |
dc.date.issued | 2011-03-02 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126769 | - |
dc.description.abstract | Background: Prognostic indexes are useful to guide tailored treatment strategies for cancer patients with brain metastasis (BM). We evaluated the new Graded Prognostic Assessment (GPA) scale in a prospective validation study to compare it with two published prognostic indexes. Methods: A total of 285 newly diagnosed BM (n = 85 with synchronous BM) patients, accrued prospectively between 2000 and 2009, were included in this analysis. Mean age was 62 +/- 12.0 years. The median KPS and number of BM was 70 (range, 20-100) and 3 (range, 1-50), respectively. The majority of primary tumours were lung (53%), or breast (17%) cancers. Treatment was administered to 255 (89.5%) patients. Only a minority of patients could be classified prospectively in a favourable prognostic class: GPA 3.5-4: 3.9%; recursive partitioning analysis (RPA) 1, 8.4% and Basic Score for BM (BSBM) 3, 9.1%. Mean follow-up (FU) time was 5.2 +/- 4.7 months. Results: During the period of FU, 225 (78.9%) patients died. The 6 months-and 1 year-OS was 36.9% and 17.6%, respectively. On multivariate analysis, performance status (P < 0.001), BSBM (P < 0.001), Center (P = 0.007), RPA (P = 0.02) and GPA (P = 0.03) were statistically significant for OS. The survival prediction performances' of all indexes were identical. Noteworthy, the significant OS difference observed within 3 months of diagnosis between the BSBM, RPA and GPA classes/groups was not observed after this cut-off time point. Harrell's concordance indexes C were 0.58, 0.61 and 0.58 for the GPA, BSBM and RPA, respectively. Conclusions: Our data suggest that the new GPA index is a valid prognostic index. In this prospective study, the prediction performance was as good as the BSBM or RPA systems. These published indexes may however have limited long term prognostication capability. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/1748-717X-6-23 | - |
dc.relation.ispartof | Radiation Oncology, 2011, vol. 6, num. 23 | - |
dc.relation.uri | https://doi.org/10.1186/1748-717X-6-23 | - |
dc.rights | 8 p. | - |
dc.rights | cc by (c) Villà, Salvador et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Metàstasi | - |
dc.subject.classification | Malalties cerebrals | - |
dc.subject.other | Metastasis | - |
dc.subject.other | Brain diseases | - |
dc.title | Validation of the new graded prognostic assessment scale for brain metastases: a multicenter prospective study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2018-07-24T13:01:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21366924 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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