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Title: A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
Author: McKay, James D.
Truong, Therese
Gaborieau, Valerie
Chabrier, Amelie
Chuang, Shu-Chun
Byrnes, Graham
Zaridze, David
Shangina, Oxana
Szeszenia-Dabrowska, Neonila
Lissowska, Jolanta
Rudnai, Peter
Bueno de Mesquita, H. Bas
Vatten, Lars
Njølstad, Inger
Goodman, Gary E.
Field, John K.
Hallmans, Göran
Liloglou, Triantafillos
Vineis, Paolo
Clavel-Chapelon, Françoise
Palli, Domenico
Bencko, Vladimir
Key, Timothy
Tumino, Rosario
Peeters, Petra H. M.
Krogh, Vittorio
Panico, Salvatore
González, Carlos A.
Overvad, Kim
Quirós, J. Ramón
Martínez, Carmen
Navarro, Carmen
Riboli, Elio
Ardanaz, Eva
Larrañaga, Nerea
Trichopoulou, Antonia
Linseisen, Jakob
Boeing, Heiner
Tjønneland, Anne
Fabianova, Eleonora
Kumle, Merethe
Välk, Kristjan
Voodern, Tõnu
Metspalu, Andres
Lagiou, Pagona
Zelenika, Diana
Boland, Anne
Delepine, Marc
Foglio, Mario
Merletti, Franco
Lechner, Doris
Bucur, Alexandru
Holcatova, Ivana
Blanché, Hélène
Gut, Ivo G.
Galan, Pilar
Trichopoulos, Dimitrios
Heath, Simon
Hashibe, Mia
Hayes, Richard B.
Richiardi, Lorenzo
Boffetta, Paolo
Lathrop, Mark
Brennan, Paul
Janout, Vladimir
Foretova, Lenka
Benhamou, Simone
Bouchardy, Christine
Ahrens, Wolfgang
Talamini, Renato
Barzan, Luigi
Kjaerheim, Kristina
Cadoni, Gabriella
Macfarlane, Gary J.
Macfarlane, Tatiana V.
Simonato, Lorenzo
Canova, Cristina
Luo, Jingchun
Agudo, Antonio
Castellsagué, Xavier
Neto, José Eluf
Lowry, Ray
Conway, David I.
McKinney, Patricia A.
Arzani, Dario
Healy, Claire M.
Toner, Mary E.
Znaor, Ariana
McClean, Michael D.
Curado, Maria Paula
Koifman, Sergio
Menezes, Ana
Fernández Garrote, Leticia
Boccia, Stefania
Olshan, Andrew F.
Weissler, Mark C.
Funkhouser, William K.
Lubiński, Jan
Trubicka, Joanna
Lener, Marcin
Romkes, Marjorie
Oszutowska, Dorota
Schwartz, Stephen M.
Chen, Chu
Fish, Sherianne
Manni, Johannes J.
Doody, David R.
Muscat, Joshua E.
Lazarus, Philip
Marsit, Carmen J.
Gallagher, Carla J.
Chang, Shen-Chih
Buch, Shama
Zhang, Zuo-Feng
Wei, Qingyi
Sturgis, Erich M.
Peters, Wilbert H. M.
Wang, Li-E
Franceschi, Silvia
Herrero, Rolando
Kelsey, Karl T.
Nelson, Hh
Nukui, Tomoko
Zhong, Shilong
Lacko, Martin
Khaw, Kay-Tee
Hung, Rayjean J.
McLaughlin, John
Keywords: Consum d'alcohol
Drinking of alcoholic beverages
Issue Date: 17-Mar-2011
Publisher: Public Library of Science (PLoS)
Abstract: Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p <= 5 x 10(-7)). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1 x 10(-8)) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2 x 10(-8)) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 x 10(-8); rs1229984-ADH1B, p = 7 x 10(-9); and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
Note: Reproducció del document publicat a:
It is part of: PLoS Genetics, 2011, vol. 7, num. 3, p. e1001333
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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