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DC Field | Value | Language |
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dc.contributor.author | Purdue, Mark P. | - |
dc.contributor.author | Johansson, Mattias | - |
dc.contributor.author | Zelenika, Diana | - |
dc.contributor.author | Toro, Jorge R. | - |
dc.contributor.author | Scelo, Ghislaine | - |
dc.contributor.author | Moore, Lee E. | - |
dc.contributor.author | Prokhortchouk, Egor | - |
dc.contributor.author | Wu, Xifeng | - |
dc.contributor.author | Kiemeney, Lambertus A. L. M. | - |
dc.contributor.author | Gaborieau, Valérie | - |
dc.contributor.author | Jacobs, Kevin B. | - |
dc.contributor.author | Szeszenia-Dabrowska, Neonila | - |
dc.contributor.author | Lissowska, Jolanta | - |
dc.contributor.author | Rudnai, Peter | - |
dc.contributor.author | Fabianova, Eleonora | - |
dc.contributor.author | Bucur, Alexandru | - |
dc.contributor.author | Bencko, Vladimir | - |
dc.contributor.author | Foretova, Lenka | - |
dc.contributor.author | Janout, Vladimir | - |
dc.contributor.author | Boffetta, Paolo | - |
dc.contributor.author | Colt, Joanne S. | - |
dc.contributor.author | Davis, Faith G. | - |
dc.contributor.author | Schwartz, Kendra L. | - |
dc.contributor.author | Banks, Rosamonde E. | - |
dc.contributor.author | Selby, Peter J. | - |
dc.contributor.author | Harnden, Patricia | - |
dc.contributor.author | Berg, Christine D. | - |
dc.contributor.author | Hsing, Ann W. | - |
dc.contributor.author | Grubb III, Robert L. | - |
dc.contributor.author | Boeing, Heiner | - |
dc.contributor.author | Vineis, Paolo | - |
dc.contributor.author | Clavel-Chapelon, Françoise | - |
dc.contributor.author | Palli, Domenico | - |
dc.contributor.author | Tumino, Rosario | - |
dc.contributor.author | Krogh, Vittorio | - |
dc.contributor.author | Panico, Salvatore | - |
dc.contributor.author | Duell, Eric J. | - |
dc.contributor.author | Quirós, J. Ramón | - |
dc.contributor.author | Sánchez, María José | - |
dc.contributor.author | Navarro, Carmen | - |
dc.contributor.author | Ardanaz, Eva | - |
dc.contributor.author | Dorronsoro, Miren | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Allen, Naomi E. | - |
dc.contributor.author | Bueno de Mesquita, H. Bas | - |
dc.contributor.author | Peeters, Petra H. M. | - |
dc.contributor.author | Trichopoulos, Dimitrios | - |
dc.contributor.author | Linseisen, Jakob | - |
dc.contributor.author | Ljungberg, Börje | - |
dc.contributor.author | Overvad, Kim | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Romieu, Isabelle | - |
dc.contributor.author | Riboli, Elio | - |
dc.contributor.author | Mukeriya, Anush | - |
dc.contributor.author | Shangina, Oxana | - |
dc.contributor.author | Stevens, Victoria L. | - |
dc.contributor.author | Thun, Michael J. | - |
dc.contributor.author | Diver, W. Ryan | - |
dc.contributor.author | Gapstur, Susan M. | - |
dc.contributor.author | Pharoah, Paul D. P. | - |
dc.contributor.author | Easton, Douglas F. | - |
dc.contributor.author | Albanes, Demetrius | - |
dc.contributor.author | Weinstein, Stephanie J. | - |
dc.contributor.author | Virtamo, Jarmo | - |
dc.contributor.author | Vatten, Lars | - |
dc.contributor.author | Hveem, Kristian | - |
dc.contributor.author | Njølstad, Inger | - |
dc.contributor.author | Tell, Grethe | - |
dc.contributor.author | Stoltenberg, Camilla | - |
dc.contributor.author | Kumar, Rajiv | - |
dc.contributor.author | Koppova, Kvetoslava | - |
dc.contributor.author | Cussenot, Olivier | - |
dc.contributor.author | Benhamou, Simone | - |
dc.contributor.author | Oosterwijk, Egbert | - |
dc.contributor.author | Vermeulen, Sita H. | - |
dc.contributor.author | Aben, Katja K. | - |
dc.contributor.author | Van der Marel, Saskia L. | - |
dc.contributor.author | Ye, Yuanqing | - |
dc.contributor.author | Wood, Christopher G. | - |
dc.contributor.author | Pu, Xia | - |
dc.contributor.author | Mazur, Alexander M. | - |
dc.contributor.author | Boulygina, Eugenia S. | - |
dc.contributor.author | Chekanov, Nikolai N. | - |
dc.contributor.author | Foglio, Mario | - |
dc.contributor.author | Lechner, Doris | - |
dc.contributor.author | Gut, Ivo G. | - |
dc.contributor.author | Heath, Simon C. | - |
dc.contributor.author | Blanche, Hélène | - |
dc.contributor.author | Hutchinson, Amy | - |
dc.contributor.author | Thomas, Gilles | - |
dc.contributor.author | Wang, Zhaoming | - |
dc.contributor.author | Yeager, Meredith | - |
dc.contributor.author | Fraumeni, Joseph F. | - |
dc.contributor.author | Skryabin, Konstantin G. | - |
dc.contributor.author | McKay, James D. | - |
dc.contributor.author | Rothman, Nathaniel | - |
dc.contributor.author | Chanock, Stephen J. | - |
dc.contributor.author | Lathrop, Mark | - |
dc.contributor.author | Brennan, Paul | - |
dc.contributor.author | Chow, Wong-Ho | - |
dc.contributor.author | Zaridze, David | - |
dc.contributor.author | Matveev, Vsevolod | - |
dc.contributor.author | Lubinski, Jan | - |
dc.contributor.author | Trubicka, Joanna | - |
dc.date.accessioned | 2018-12-07T11:40:40Z | - |
dc.date.available | 2018-12-07T11:40:40Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/126785 | - |
dc.description.abstract | We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r(2) = 0.99 in controls), rs11894252 (P = 1.8 x 10(-8)) and rs7579899 (P = 2.3 x 10(-9)), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 x 10(-14)). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 x 10(-8)). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1038/ng.723 | - |
dc.relation.ispartof | Nature Genetics, 2011, vol. 43, num. 1, p. 60-65 | - |
dc.relation.uri | https://doi.org/10.1038/ng.723 | - |
dc.rights | (c) Purdue et al., 2011 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de ronyó | - |
dc.subject.classification | Genòmica | - |
dc.subject.other | Kidney cancer | - |
dc.subject.other | Genomics | - |
dc.title | Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2018-07-24T13:02:26Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21131975 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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PurdueMP.pdf | 360.91 kB | Adobe PDF | View/Open |
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